– Activin Follistatin Biology and Inflammation
– Brain and Gender
– Embryo Implantation
– Endocrinology and immunophysiology
– Endometrial Remodelling
– Implantation and Placental Development
– Male Fertility Regulation
– Testis Development and Male Germ Cell Biology
Research > Centre for Reproductive Health > Activin Follistatin Biology and Inflammation
Research Group Heads: Professor David de Kretser AC, Associate Professor Mark Hedger
The Activin Follistatin Biology and Inflammation group’s work focuses on improving understanding of how the inhibins, activins and follistatin control FSH secretion by the pituitary gland. Ongoing studies directed by both Associate Professor Mark Hedger and Professor David de Kretser have focussed on the role that these proteins have in the control of inflammation and tissue repair.
Their studies have shown that activin A and B are critically important in the initiation of the inflammatory cascade and drive the resolution of the inflammatory response towards fibrosis and scar formation. These actions raise the possibility that the activins and follistatin may be important sensitive diagnostic markers of inflammatory disease and that follistatin can control the outcome of serious inflammatory challenges.
Professor David de Kretser (Research Group Co-Head)
Associate Professor Mark Hedger (Research Group Co-Head)