Brain and Gender

ResearchCentre for Endocrinology and Metabolism > Brain and Gender

lab-picBrain and Gender

Research Group Head: Dr Joohyung Lee and Professor Vincent Harley

Genetic differences between the male and female brain may hold the key to understanding gender prevalence of neurological disorders. The Brain and Gender group uses a combination of biochemical, molecular genetic, anatomical, and behavioural approaches to investigate the underlying mechanisms that contribute to brain sex differences and sex bias in the prevalence and progression of brain diseases.

Research Projects:


Research Group:

Dr Joohyung Lee (Co-Research Group Head)
Professor Vincent Harley (Co-Research Group Head)

Selected Publications:

Czech DP*, Lee J*, Correia J, Loke H, Möller E, Harley VR (2014) Transient neuroprotection by SRY up-regulation in dopamine cells following injury in males. Endocrinology. Apr 7 [Epub] PMID: 24708242 (joint first author)

Lee, J. and Harley, V. (2012) The male fight-flight response: A result of SRY regulation of   catecholamines? Bioessays. 34(6): 545-7

Czech, D.P., Lee, J., Sim, H., Parish, C.L., Vilain, E. and Harley, V.R. The human testis determining factor SRY localizes in the substantia nigra and regulates multiple components of dopamine synthesis and metabolism. (2012) Journal of Neurochemistry 122(2): 260-271

Hare, L., Bernard, P., Sánchez, F.J., Baird, P.N., Vilain, E., Kennedy, T. and Harley, V.R. (2009) Androgen receptor repeat length polymorphism associated with male-to-female transsexualism. Biological Psychiatry 65: 93-96

Dewing, P., Chiang, C.W.K., Sinchak, K., Sim, H., Fernagut, P.-O., Kelly, S., Chesselet, M.-F., Micevych, P.E., Albrecht, K.H., Harley, V.R. and Vilain, E. (2006) Direct regulation of adult brain function by the male-specific factor SRY. Current Biology 16: 415-420