Growth Factor Signalling

ResearchCentre for Endocrinology and Metabolism > Growth Factor Signalling

test_tubes1Growth Factor Signalling

Research Group Head: A/Prof Craig Harrison

Members of the transforming growth factor-β (TGF-β) protein superfamily play a key role in the regulation of cellular growth and differentiation. These proteins have documented roles in embryogenesis and reproduction, as well as wound healing, immune function, fibrosis and tumour progression. Our group has a long-term interest in understanding the mechanisms that govern the regulation of individual members of the TGF-β family and their impact on biological activity.

Research Projects:

 

Research Group:

A/Prof Craig Harrison (Research Group Head)
Dr Kelly Walton

Selected publications:

Walton KL, Makanji Y, Wilce MC, Chan KL, Robertson DM and HARRISON CA (2009) A common biosynthetic pathway governs the dimerisation and secretion of inhibin and related TGF-β ligands. J Biol Chem. 284:9311.

Walton K., Makanji Y, Chen J, Chan KL, Wilce MC, Robertson DM and HARRISON CA (2010) Two distinct regions of latency associated peptide coordinate stability of the latent TGF-β1 complex. J Biol Chem 285:17029-17037.

Makanji Y, Walton KL, Chan KL, Gregorevic P, Robertson DM, HARRISON CA (2011) Generation of a specific activin antagonist by modification of the activin A propeptide. Endocrinology 152:3758–3768.

Nicholls PK, Stanton PG, Chen JL, Olcorn JS, Haverfield JT, Qian H, Walton KL, Gregorevic P, HARRISON CA. (2012) Activin Signaling Regulates Sertoli Cell Differentiation and Function. Endocrinology 153:6065-6077.

Chen JL, Walton KL, Winbanks CE, Murphy KT, Thomson RE, Makanji Y, Qian H, Lynch GS, HARRISON CA* and Gregorevic P* (*Co-last author) (2014) Elevated expression of activins promotes muscle wasting and cachexia. FASEB Journal 28:1711-1723.