Leukaemia Research

Research > Centre for Cancer Research > Leukaemia Research

immunityLeukaemia Research

Research Group Co-Heads: Dr Ashish Banerjee and Dr George Grigoriadis

We are interested in signalling pathways that control homeostasis and function of immune cells in health and disease.

  • The role of the NF-kB transcription factor RelA in T regulatory cell homeostasis and function
  • The role of the bone marrow environment in evolution of myeloid dysplasia
  • Therapeutic benefits of iron chelation in MDS

 

Research Group:

Dr Ashish Banerjee (Research Group Co-Head)
Dr George Grigoriadis (Research Group Co-Head)

Research Project:

The role of the NF-kB transcription factor RelA in T regulatory cell homeostasis and function

Publications:

c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells. Grigoriadis G, Vasanthakumar A, Banerjee A, Grumont R, Overall S, Gleeson P, Shannon F, Gerondakis S.PLoS One. 2011;6(10):e26851. doi: 10.1371/journal.pone.0026851. Epub 2011 Oct 31.

Modulating T regulatory cells in cancer: how close are we? Banerjee A, Vasanthakumar A, Grigoriadis G.Immunol Cell Biol. 2013 May;91(5):340-9.

Thymic regulatory T cell development: role of signalling pathways and transcription factors.Engel M, Sidwell T, Vasanthakumar A, Grigoriadis G, Banerjee A.Clin Dev Immunol. 2013;2013:617595. doi: 10.1155/2013/617595. Epub 2013 Sep 26. Review.

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S. J Exp Med. 2009 Dec 21;206(13):3001-14

NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms. Banerjee A, Grumont R, Gugasyan R, White C, Strasser A, Gerondakis S. Blood. 2008 Dec 15;112(13):5063-73

Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Banerjee A, Gugasyan R, McMahon M, Gerondakis S.Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3274-9.

Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models. Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W, Banerjee A.Oncogene. 2006 Oct 30;25(51):6781-99. Review.

Coordinating TLR-activated signaling pathways in cells of the immune system. Banerjee A, Gerondakis S. Immunol Cell Biol. 2007 Aug-Sep;85(6):420-4. Epub 2007 Jul 17. Review.

Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease. Lancaster GI, Kowalski GM, Estevez E, Kraakman MJ, Grigoriadis G, Febbraio MA, Gerondakis S, Banerjee A. PLoS One. 2012;7(6):e39100. doi: 10.1371/journal.pone.0039100. Epub 2012 Jun 11.

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.Grigoriadis G, Zhan Y, Grumont RJ, Metcalf D, Handman E, Cheers C, Gerondakis S. EMBO J. 1996 Dec 16;15(24):7099-107.