Profile – Professor Eva Dimitriadis

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Professor Eva Dimitriadis

eva_dimitriadis

Research Group Head, Embryo Implantation Laboratory
NHMRC Senior Research Fellow
Adjunct Associate Professor, Department of Anatomy and Developmental Biology, Monash University
Lecturer, Education Program in Reproductive Biology, Monash University
email: evdokia.dimitriadis@hudson.org.au

After completing a BSc degree in Melbourne, Associate Professor Eva Dimitriadis gained 8 years experience as a research assistant in Melbourne, Munich and Dublin following which she completed her PhD studies at Trinity College Dublin, Ireland. She then undertook post-doctoral studies in the University of Dublin before returning to Australia to begin her research in reproductive biology at PHI now Hudson Institute of Medical Research.

Associate Professor Dimitriadis has a passion in understanding infertility, what factors contribute to making the endometrium receptive to an implanting embryo and endometrial-trophoblast interactions during implantation. Her program includes investigating non-invasive biomarkers of implantation potential. She has a strong focus on microRNA regulation of these processes and investigating novel sustained release targeted delivery options. A number of her projects have a clinical translational focus are in pre-clinical trials.

She also has a strong interest in developing new non-hormonal contraceptives that also prevent sexually transmitted diseases and the development of novel treatments for endometrial cancer.

Associate Professor Dimitriadis has International, national and Industry collaborations including Monash IVF, the Walter Eliza Hall Institute of Medical Research, Monash University, University of Melbourne, University of Tokyo, Commonwealth Serum Laboratories and the Karolinska Instituet in Sweden.

Selected publications:

Winship, A, Van Sinderen, M, Heffernan-Marks, A, Dimitriadis, E. Chondroitin sulfate proteoglycan protein is stimulated by interleukin 11 and promotes endometrial epithelial cancer cell proliferation and migration. Int. J. Oncol. 2017 Jan 13.

Winship, A, Dimitriadis, E. Interleukin 11 induces preterm birth and modulates decidual inflammasome gene expression in mice.Placenta 2017 Feb; 50:99-101.

Winship, A, Van Sinderen, M, Rainczuk, K, Dimitriadis, E.  Therapeutically blocking Interleukin-11 Receptor-a enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours. Oncotarget 2017 Feb 8 (Epub ahead of print).

Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Görg B, Häussinger D, Lokau J, Floss DM, Piekorz R, Dimitriadis E, Garbers C, Scheller J. Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor. Cell Reports. 2016 Jul 26;16(4):1067-81.

Evans, J, Salamonsen, LA, Winship, A, Menkhorst, E, Nie, G, Gargett, C, Dimitriadis, E.  Fertile ground:  human endometrial programming and lessons in health and disease.  Nature Reviews Endocrinology 2016. (Epub ahead of print).

Winship, AL, Van Sinderen, M, Donoghue, J, Rainczuk, K, Dimitriadis, E (2016) Targeting Interleukin-11 receptor-a impairs human endometrial cancer cell proliferation and invasion in vitro and reduces tumour growth and metastasis in vivo.  Mol Cancer Ther. Feb 4. (Epub ahead of print.)

Winship AL, Koga K, Menkhorst E, Van Sinderen M, Rainczuk K, Nagai M, Cuman C, Yap J, Zhang JG, Simmons D, Young MJ, Dimitriadis E (2015) Interleukin-11 alters placentation and causes preeclampsia features in mice. Proc Natl Acad Sci USA.  Dec 29;112(52):15928-33.

Cuman C, Van Sinderen M, Gantier MP, Rainczuk K, Sorby K, Rombauts L, Osianlis T, Dimitriadis E (2015) Human Blastocyst Secreted microRNA Regulate Endometrial Epithelial Cell Adhesion.  EBioMedicine. Sept 11;2(10):1528-35. eCollection 2015 Oct.

Winship, A, Correia, J, Krishnan, T, Menkhorst, E, Cuman, C, Zhang, JG, Nicola, NA, Dimitriadis, E (2015) Blocking Endogenous Leukemia Inhibitory Factor During Placental Development in Mice Leads to Abnormal Placentation and Pregnancy Loss. Sci Rep. Aug 14; 5:13237.

Menkhorst, E, Koga, K, Van Sinderen, M, Dimitriadis, E (2014) Galectin-7 serum levels are altered prior to the onset of pre-eclampsia. Apr;35(4):281-5.

Cuman C, Menkhorst EM, Rombauts LJ, Holden S, Webster D, Bilandzic M, Osianlis T, Dimitriadis E (2013) Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to IVF success. Hum Reprod. May;28(5):1161-71.

Menkhorst EM, Lane N, Winship AL, Li P, Yap J, Meehan K, Rainczuk A, Stephens A, Dimitriadis E (2012) Decidual-secreted factors alter invasive trophoblast membrane and secreted proteins implying a role for decidual cell regulation of placentation. PLoS One 7(2):e31418

Menkhorst E, Zhang J-G, Sims NA, Morgan PO, Soo P, Poulton IJ, Metcalf D, Alexandrou E, Gresle M, Salamonsen LA, Buzkueven H4, Nicola NA, Dimitriadis E (2011) Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice. PLoS One 6(5):e19665

Marwood M, Visser K, Salamonsen LA, Dimitriadis E (2009) Interleukin 11 and leukaemia inhibitory factor regulate the adhesion of endometrial epithelial cells: implications in fertility regulation. Endocrinology 150:2915-2923.

White CA, Zhang J-G, Salamonsen LA, Baca M, Fairlie WD, Metcalf D, Nicola NA, Robb L, Dimitriadis E (2007) Blocking leukemia inhibitory factor action in the uterus using a novel PEGylated antagonist prevents implantation: a new non-hormonal contraceptive strategy. Proc Natl Acad Sci USA 104(49):19357-62. (Editorial in Science and PNAS cover feature)