Profile – Dr Andrew Stephens

Research > Centre for Cancer Research > Scientists and Staff > Dr Andrew Stephens

Dr Andrew Stephens

andrew_stephens

Research Group Head, Ovarian Cancer Biomarkers
OCRF Research Fellow

email: andrew.n.stephens@hudson.org.au

After completing a PhD in the Department of Biochemistry at Monash University, Dr Andrew Stephens completed postdoctoral training at the University of Sydney. In 2006, he returned to Melbourne where he joined the Hudson Institute.

In 2006, he accepted the position of NAB Ovarian Cancer Research Foundation Fellow and Head of the Ovarian Cancer Biomarkers Research Group.

Currently an Ovarian Cancer Research Foundation (OCRF) Research Fellow, Dr Stephens is passionate about reducing the mortality of ovarian cancer. A leading authority on the application of proteomics technologies, his work aims to better understand the development of ovarian tumours and identify specific biological events useful as markers of early-stage disease.

He is also working to improve treatment and management of the disease through development of novel targeted therapies.

Selected publications

Rainczuk A, Rao JR, Gathercole JL, Fairweather NJ, Chu S, Masadah R, Jobling TW, Stephens AN (2014) Evidence for the antagonistic form of CXC-motif chemokine CXCL10 in serous epithelial ovarian tumours. Int J Cancer 134:530-541.

Lamon S, Zacharewicz E, Stephens AN, Russell AP (2014) EPO-receptor is present in C2C12 and human primary skeletal muscle cells but EPO does not contribute to myogenesis. Physiol Rep 2:e00256.

Rainczuk A, Condina M, Pelzing M, Dolman S, Rao JR, Fairweather NJ, Jobling TW, Stephens AN (2013) The utility of isotope-coded protein labeling for prioritization of proteins found in ovarian cancer patient urine. J Prot Res 12:4074-4088.

Singh H, Li Y, Fuller PJ, Harrison C, Rao J, Stephens AN, Nie G (2013). HtrA3 is downregulated in cancer cell lines and significantly reduced in primary serous and granulosa cell ovarian tumors. J Cancer 4:152-164.

Stanton PG, Sluka P, Foo CFH, Stephens AN, Smith AI, McLachlan RI, O’Donnell L (2012) Proteomic changes in rat spermatogenesis in response to in vivo androgen manipulation; impact on meiotic cells. PLoS One 7:e41718.

Singh H, Makino S, Endo Y, Li Y, Stephens AN, Nie G (2012) Application of the wheat-germ cell-free translation system to produce high temperature requirement A3 (HtrA3) proteases. Biotechniques 52:23-28.

Heng S, Cervero A, Simon C, Stephens AN, Li Y, Zhang J, Paule S, Rainczuk A, Singh H, Quinonero A, Tapia A, Velasquez L, Salamonsen L, Rombauts LJF, Nie G (2011) Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions. Endocrinology 152:5041-5052.

Paule S, Meehan K, Rainczuk A, Stephens AN, Nie G (2011) Combination of hydrogel nanoparticles and proteomics to reveal secreted proteins associated with decidualization of human uterine stromal cells. Proteome Science 9:50.

Paule SG, Airey LM, Li Y, Stephens AN, Nie GY (2010) Proteomic approach identifies alterations in cytoskeletal remodelling proteins during decidualization of human endometrial stromal cells. J Proteome Res 9:5739-5747.

Heng S, Paule S, Hardman B, Li Y, Singh H, Rainczuk A, Stephens AN, Nie G (2010) Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. Endocrinology 151:3909-3917.

Stephens AN, Hannan NJ, Rainczuk A, Meehan KL, Chen J, Nicholls PK, Rombauts LJF, Stanton PG, Robertson DM, Salamonsen LA (2010) Post-translational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE. J Proteome Res 9:2438-2449.

Stephens AN, Pereira-Fantini PM, Wilson G, Taylor RG, Rainczuk A, Meehan KL, Sourial M, Fuller PJ, Stanton PG, Robertson DM, Bines JE (2010) Proteomic analysis of the intestinal adaptation response reveals altered expression of fatty acid binding proteins following massive small bowel resection. J Proteome Res 9:1437-1449. (This article was featured in a one-page editorial in J Proteome Res 9:1194.)

Rainczuk A, Meehan K, Steer DL, Stanton PG, Robertson DM, Stephens AN (2010) An optimized procedure for the capture, fractionation and proteomic analysis of proteins using hydrogel nanoparticles. Proteomics 10:332-336.

Kilpatrick LM*, Stephens AN*, Hardman BM, Salamonsen LA, Li Y, Stanton PG, Nie G (2009) Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment. J Proteome Res 8:4983-4992. (*joint first authors)

Chen JI-C, Hannan NJ, Mak Y, Nicholls PK, Zhang J, Rainczuk A, Stanton PG, Robertson DM, Salamonsen LA, Stephens AN (2009) Proteomic characterization of midproliferative and midsecretory human endometrium. J Proteome Res 8:2032-2044. (This article was one of the ‘top 10 most accessed articles during the 3rd quarter of 2010’ in J Proteome Res.)