Profile – Dr Anthony J Sadler

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Dr Anthony Sadler

anthony-sadler-web
Research Group Co-Head, Cancer and Innate Immunity

email: anthony.sadler@hudson.org.au

Dr Anthony Sadler is expert in innate immunity. After completing his early research training in microbial genetics at the University of Canterbury and virology at the University of Otago, he travelled to the US where he conducted postdoctoral research into host immune responses to microbial pathogens at the Department of Cancer Biology within the Learner Research Institute. In 2007, Dr Sadler came to Australia, where he took up a position as a Senior Research Fellow within the Hudson Institute’s Centre for Cancer Research. His research group investigates innate immune responses that drive inflammation. Dr Sadler’s research has advanced our knowledge of the regulation of cell signalling pathways that control responses to our environment. His research aims to characterise mechanisms that cause inflammation, to be able to identify strategies to curb inflammatory pathologies and ensuing disease.

Selected publications

Yim HCH, Wang D, Yu L, White CL, Faber PW, Williams BRG, Sadler AJ (2016) The kinase activity of PKR represses inflammasome activity. Cell Res 26:367-379.

Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HCH, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu J-P, Watkins DN, Gerondakis S, Williams BRG, Xu D (2015) BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci USA 112:1535-1540.

Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST, Banerjee A, Mansell AS, Liu J-P, Gerondakis S, Williams BRG, Xu D (2015) The acetyltransferase HAT1 moderates the NF-kappaB response by regulating the transcription factor PLZF. Nat Commun 6:6795.

Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BRG (2009) Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity. Immunity 30:802-816.

Yuan X, Yu L, Li J, Xie G, Rong T, Zhang L, Chen J, Meng Q, Irving AT, Wang D, Williams ED, Liu J-P, Sadler AJ, Williams BRG, Shen L, Xu D (2013) ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton. Cancer Res 73:3625-3637.

Irving AT, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton AH, Szczepny A, Morimoto H, Xu D, Williams BRG, Sadler AJ (2012) Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense. Immunity 36:795-806.

Sadler AJ, Latchoumanin O, Hawkes D, Mak J, Williams BRG (2009) An antiviral response directed by PKR phosphorylation of the RNA helicase A. PLoS Pathog 5:e1000311.

Sadler AJ, Williams BRG (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8:559-568.