Profile – Dr Daniel Gough

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Dr Daniel Gough

dan_gough

 

Research Group Head, STAT Cancer Biology
NHMRC Career Development Fellow

email: daniel.gough@hudson.org.au

Dr Daniel Gough is a biochemist and cancer biologist, and the head of the STAT Cancer Biology group in the Centre for Cancer Research at Hudson Institute of Medical Research. Dr Gough’s research focuses on signal transduction pathways, which engage the Signal Transducer and Activator of Transcription (STAT) proteins in normal development, and how these pathways alter in childhood cancers.

After completing his BSc (2000) and BSc (Hons) (2001) in the Department of Pathology at the University of Melbourne, and PhD (2006) at the Peter MacCallum Cancer Centre, Dr Gough moved to New York University in the USA for postdoctoral training with Professor David E Levy (Dr Louis A. Schneider Professor of Molecular Pathology and Professor of Microbiology, and Associate Dean for Collaborative Science). During this time Dr Gough defined a mitochondrial and metabolic role for STAT3, which is necessary for cancers driven by Ras mutation. In 2012, Dr Gough was recruited to return to Australia to start his laboratory.

Selected Publications

Gough DJ*, Marié IJ, Lobry C, Aifantis I, Levy DE* (2014) STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation. Blood 124:2252-2261. (*corresponding author)

Gough DJ*, Koetz L, Levy DE* (2013) Ras oncogenes induce serine phosphorylation of mitochondrial STAT3 via an Erk dependent pathway necessary for transformation. PLoS One 8:e83395. (*corresponding author)

Gough DJ, Messina NL, Clarke CJP, Johnstone RW, Levy DE (2012) Constitutive type I interferon positively and negatively modulates homeostatic balance through tonic signaling. Immunity 36:166-174.

Gough DJ, Messina NL, Gould JA, Hertzog PJ, Sabapathy K, Trapani JA, Levy DE, Clarke CJP, Johnstone RW (2010) Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol 8:e1000361.

Gough DJ, Corlett A, Schesslinger K, Wegrzyn J, Larner AC, Levy DE (2009) Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 324:1713-1716.

Gough DJ, Sabapathy K, Ko EY, Arthur HA, Schreiber RD, Trapani JA, Clarke CJ, Johnstone RW (2006) A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of IFN gamma-response genes. J Biol Chem 282:938-946.