Profile – Prof Kate Loveland

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Professor Kate Loveland

288_Kate Loveland_20160531

Centre Head, Centre for Reproductive Health
Research Group Head, Testis Development and Male Germ Cell Biology

NHMRC Senior Research Fellow
Head of Postgraduate Studies, School of Clinical Sciences,
Monash Health Translational Precinct
Adjunct Professor, Department of Anatomy & Developmental Biology, Monash University
Liebig Professor, Justus-Liebig University, Giessen, Germany
email: kate.loveland@hudson.org.au, kate.loveland@monash.edu

 

Professor Loveland received her undergraduate and PhD degrees at Duke University the United States, studying the molecular basis of mammalian fertilization. Her laboratory investigates the molecular and cellular mechanisms that underpin mammalian testis development and sperm production. The team’s objective is to identify and characterise the molecular switches that regulate cell fate decisions in sperm precursor cells (germ cells) and in the somatic cells that support them.  Specific research focus areas are: Signalling by activin/ TGFβ superfamily, Wnt and Hedgehog pathways, growth factor/hormone signalling cross-talk, and the contribution of regulated nuclear transport molecules to cellular development and stress responses.

She is a National Health and Medical Research Council of Australia Senior Research Fellow (since 2000) and is a Fellow of the Society for the Study of Reproduction. She received the American Society for Andrology Young Andrologist Award in 2004 and the Monash University Vice Chancellor’s Award for Excellence in Postgraduate Supervision in 2010. In 2014 she was granted an Honorary Liebig Professorship from the Justus-Liebig University in Giessen, Germany for her joint role in leading establishment of an International PhD Research Training Group in the Pathogenesis of Male Reproduction (2013-2017). Prof. Loveland’s professional roles for her discipline include Society for Reproductive Biology: Program Chair, and Treasurer; American Society for Andrology: Annual Meeting Program co-Chair (2010), Founder and Chair of the Basic Science Workshop, President of Women in Andrology and Council member; Society for the Study of Reproduction: International Members Subcommittee Chair, Director, and Annual Meeting Program co-Chair (2017).

Prof. Loveland has published over 130 peer-reviewed manuscripts, and she is currently serving as an Associate Editor for Andrology.

Selected Recent Publications

Reviews

  1. Loveland, K.L. and Hedger, M.P. 2015. Activins and inhibins in Sertoli cell biology: Implications for testis development and function. In: M. Griswold, ed. Sertoli Cell Biology. Elsevier Science (USA). pp 201-221.
  2. Loveland K., Major A., Butler R., Young J., Jans D.A., Miyamoto Y. (2015) Putting things in place for fertilization: Discovering roles for importin proteins in cell fate and spermatogenesis. Asian Journal of Andrology, 2015 May 18. doi: 10.4103/1008-682X.154310.
  3. De Kretser, D.M., O’Bryan M.K. and Loveland, K.L. (2015). Spermatogenesis. In: eds Jameson/DeGroot: Endocrinology: Adult & Pediatric, 7/E. Elsevier.
  4. McIver, S. C., Roman, S.D., Nixon, B. Loveland, K.L. and McLaughlin, E. A. 2013. The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets. F1000 Research. Feb 19;2:55. eCollection 2013.
  5. Itman, C. and Loveland, K.L. (2013) Smads and cell fate: distinct roles in specification, development and tumourigenesis in the testis. IUBMB Life. 65(2):85-97.
  6. Barakat, B., Itman, C., Mendis, S. and Loveland, K.L. (2012) Activins and inhibins in mammalian testis development: new models, new insights. Invited review. Molecular and Cellular Endocrinology. 359:66-77.
  7. Miyamoto, Y., Boag, P., Hime, G., and Loveland, K.L. (2012) Regulated nucleocytoplasmic transport during gametogenesis. BBA – Gene Regulatory Mechanisms. 1819:616-30.

 

Primary Data Publications

  1. Itman C, Bielanowicz A, Goh H, Lee Q, Fulcher AJ, Moody SC, Doery JCG, Martin J, Eyre S, Hedger MP, Loveland KL (2015) Murine inhibin alpha subunit haploinsufficiency causes transient abnormalities in prepubertal testis development followed by adult testicular decline. Endocrinology. Mar 17:en20141555.
  2. Major AT, Hogarth CA, Miyamoto Y, Sarraj MA, Smith CL, Koopman P, Kurihara Y, Jans DA, Loveland KL. (2015) Specific interaction with the nuclear transporter importin alpha 2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles. Biol. Cell. 26:1543-58.
  3. Arjomand A, Baker MA, Li C, Buckle AM, Jans DA, *Loveland KL, *Miyamoto Y. (2014) The α-importome of mammalian germ cell maturation provides novel insights for importin biology. FASEB J. 201428(8):3480-93. * Equal contributors. .^Primary supervisor of first author.
  4. Jørgensen A, Young J, Nielsen JE, Joensen UN, Toft BG, *Rajpert-De Meyts E, *Loveland KL. (2014). Hanging drop cultures of human testis and testis cancer samples used to investigate activin treatment effects in a preserved niche. * Equal contributors. Br. J. Cancer. 110(10):2604-14.
  5. Sahin Z, Szezepny A, McLaughlin EA, Meistrich ML, Zhou W, Unstunel I, Loveland, KL. (2014) Dynamic Hedgehog signalling pathway activity in germline stem cells. Andrology. 2(2):267-74.
  6. Kerr G, Young, J, Horvay K, Abud H, Loveland KL. (2014) Intrinsic regulation of Wnt/beta-catenin signaling is required for adult spermatogenesis. Biology of Reproduction. 90(1):3. doi: 10.1095/biolreprod.112.105809.
  7. Moody, S., Goh, H., Loveland, K.L., Itman, C. (2013) Prepubertal mouse testis growth and maturation and androgen production are acutely sensitive to di-n-butyl phthalate. Endocrinology. 154(9):3460-75.
  8. Young, J.C., Ly-Hyunh, J., Lescesen, H., Miyamoto, Y, Browne, C., Yoneda, Y., Koopman, P., Loveland, K.L. *, Jans, D.A*. (2013) The nuclear import factor importin a4 can protect against oxidative stress. Biochim Biophys Acta – Molecular Cell Research 1833(10):2348-56. * equal contributors.
  9. Tarulli,G.A., Stanton, P.G., Loveland,K.L., Rajpert-De Meyts, E., McLachlan, R.I., and Meachem, S.J. (2013) A survey of Sertoli cell differentiation in men after gonadotropin suppression and in testicular cancer. Spermatogenesis. 3:1-7.