Profile – Prof Matthew Gillespie

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Professor Matthew Gillespie

matt_gillespie_web

Research Group Head, Bone, Joint & Cancer
Centre for Endocrinology and Metabolism

Associate Dean (Research Strategy), Faculty of Medicine, Nursing and Health Sciences

email: matthew.gillespie@monash.edu

Trained in microbiology and immunology, Professor Matthew Gillespie is an internationally respected bone cell biologist and cancer researcher and is Associate Dean (Research Strategy) within the Faculty of Medicine, Nursing and Health Sciences, Monash University. He was Director of Prince Henry’s Institute 2008-2013, and has held high-level research administration roles in other leading research organisations, including as Associate Director of Melbourne’s St Vincent’s Institute of Medical Research. An active member of the Australian and global scientific communities, Professor Gillespie has held editorial roles including on the boards of Arthritis and Rheumatism, Endocrinology, Bone, and the Journal of Bone and Mineral Research and on research committees including the NHMRC Research Committee and NHMRC Audit Committee (current). He was president of the Australian and New Zealand Bone and Mineral Society (2011-2013).

Professor Gillespie’s research has focused on bone physiology and cancer, with achievements including the identification of a number of osteoclast inhibiting factors to stop bone loss and increased understanding of the actions of cancer-derived factors and their role in cancer metastasis to the bone. His novel insights into the impact of T cell-derived cytokines on the formation and resorption of bone have particular relevance for individuals with osteoporosis or rheumatoid arthritis.

Professor Gillespie’s current interests extend upon the identification of novel inhibitors of bone destruction and how the immune system plays a pivotal role for the action of so many cytokines and growth factors. The interleukins IL-12, IL-18, IL-23 and IL-33 are of particular interest to the group and their mechanism of action on T cells, osteoclasts and osteoblasts.

He continues to investigate the role of parathyroid hormone-related protein actions upon breast cancers, and determining the actions of factors derived from cancers, and their relevance to facilitate cancer metastasis to bone.

Selected Publications

Cheung, V., Bouralexis, S. and Gillespie M.T. (2013). PTHrP overexpression increases sensitivity of breast cancer cells to Apo2L/TRAIL. PLOS One. 8, e66343, 1-10

van der Kraan, A.G.J., Chai, R.C.C., Singh, P.P., Lang, B.J., Xu, J., Gillespie, M.T., Price, J.T. and Quinn, J.M.W. (2013). HSP90 inhibitors enhance differentiation and Microphthalmia transcription factor (MITF) activity in osteoclast progenitors. Biochemical Journal. 451, 235-244

Wong, P., Fuller, P.J., Gillespie, M.T., Kartsogiannis, V., Strauss, B.J., Bowden, D. and Milat, F. (2013). Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures. Osteoporosis International. 24, 1965-1971

Quach, J. M., Walker, E. C., Allan, E., Solano, M., Yokoyama, A., Kato, S., Sims, N. A., Gillespie, M. T. and Martin, T. J. (2011). Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment.Journal of Biological Chemistry. 286, 4186-4198

Saleh, H., Eeles, D., Hodge, J. M., Nicholson, G. C., Gu, R., Pompolo, S., Gillespie M. T. and Quinn, J.M. (2011) Interleukin-33, a target of parathyroid hormone and oncostatin M, increases osteoblastic matrix mineral deposition and inhibits osteoclast formation in vitro. Endocrinology. 152, 1911-1922

Quinn, J. M., Tam, S., Sims, N. A., Saleh, H., McGregor, N. E., Poulton, I. J., Scott, J. W., Gillespie, M. T., Kemp, B. E., van Denderen, B. J. (2010). Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function. FASEB Journal. 24, 275-285

Kartsogiannis, V., Sims, N.A., Quinn, J.M.W., Ly, C., Cipetic, M., Poulton, I.J., Walker, E.C., Saleh, H., McGregor, N.E., Wallace, M.E., Smyth, M.J., Martin, T.J., Zhou, H., Ng, K.W. and Gillespie, M.T. (2008). Osteoclast inhibitory lectin (OCIL), an immune cell product that is required for normal bone physiology in vivo. Journal of Biological Chemistry. 283, 30850-30860

Quinn, J.M.W., Sims, N.A., Saleh, H., Mirosa, D., Thompson, K., Bouralexis, S., Walker, E.C., Saleh, H., Martin, T.J. and Gillespie, M.T. (2008). Interleukin-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice. Journal of Immunology. 181, 5720-5729

Nakamura, A., Ly, C., Cipetic, M., Sims, N.A., Vieusseux, J., Kartsogiannis, V., Bouralexis, S., Saleh, H., Zhou, H., Price, J.T., Martin, T.J., Ng, K.W., Gillespie, M.T. and Quinn, J.M.W. (2007). Osteoclast inhibitory lectin (OCIL) inhibits osteoblast differentiation and function in vitro. Bone. 40, 305-315

Fisher, J.L., Thomas-Mudge, R.J., Elliott, J., Hards, D.K., Sims, N.A., Slavin, J., Martin, T.J. and Gillespie, M.T. (2006). Osteoprotegerin over-expression by breast cancer cells enhances orthotopic and osseous tumor growth, and contrasts with that delivered therapeutically. Cancer Research. 66, 3620-3628

Häusler, K.D., Horwood, N.J., Chuman, Y., Fisher, J.L., Ellis, J., Martin, T.J., Rubin, J.S. and Gillespie, M.T. (2004). Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. Journal of Bone and Mineral Research. 19, 1873-1881

Horwood, N.J., Elliott, J., Martin, T.J. and Gillespie, M.T. (2001). Interleukin-12 alone, and in synergy with interleukin-18, inhibits osteoclast formation in vitro. Journal of Immunology. 166, 4915-4921

Lam, M.H.C., House, C.M., Tiganis, T., Mitchelhill, K.I., Sarcevic, B., Cures, A., Ramsay, R., Kemp, B.E., Martin, T.J. and Gillespie, M.T. (1999). Phosphorylation at the cyclin dependent kinases p34cdc2 and p33cdk2 site (Thr85) of parathyroid hormone-related protein (PTHrP) negatively regulates its nuclear localization. Journal of Biological Chemistry. 274, 18559-18566

Lam, M., Briggs, L.J., Hu, W., Martin, T.J., Gillespie, M.T. and Jans, D.A. (1999). Importin b recognizes parathyroid hormone-related protein (PTHrP) with high affinity and mediates its nuclear import in the absence of importin a. Journal of Biological Chemistry. 274, 7391-7398

Thomas, R.J., Guise, T.A., Yin, J.J., Elliott, J., Horwood, N.J., Martin, T.J., and Gillespie, M.T. (1999). Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology. 140, 4451-4458