Activin Follistatin Biology and Inflammation Research Group
Research Group Head
The Activin Follistatin Biology and Inflammation group’s work is focused on improving understanding of how the inhibins, activins and follistatin control FSH secretion by the pituitary gland. Ongoing studies directed by both Associate Professor Mark Hedger and Professor David de Kretser have focussed on the role that these proteins have in the control of inflammation and tissue repair.
Their studies have shown that activin A and B are critically important in the initiation of the inflammatory cascade and drive the resolution of the inflammatory response towards fibrosis and scar formation. These actions raise the possibility that the activins and follistatin may be important sensitive diagnostic markers of inflammatory disease and that follistatin can control the outcome of serious inflammatory challenges.