Bone, Joint and Cancer Research Group
Research Group Head
Bone loss and reduced bone mass, which is commonly associated with diseases such as osteoporosis, arthritis, most cancers of the bone and transfusion-dependent thalassemia, leave patients at a high risk of fractures, pain, and other serious problems. The Bone, Joint and Cancer Group is working to identify the pathways required to build bone and limit bone destruction, as well as understand how the cells in the bone microenvironment communicate with each other. The group hopes these findings will assist in the identification of new ways to promote bone formation.
- Transfusion-dependent thalassemia and bone disease
- Spread of cancers to bone
- Apo2L/TRAIL as a regulator of cell death in transformed cells
- Prevention of bone loss
- Factors affecting osteoblast differentiation
Quinn, J.M.W., Sims, N.A., Saleh, H., Mirosa, D., Thompson, K., Bouralexis, S., Walker, E.C., Saleh, H., Martin, T.J. and Gillespie, M.T. (2008). Interleukin-23 inhibits osteoclastogenesis indirectly through lymphocytes and is required for the maintenance of bone mass in mice. Journal of Immunology. 181, 5720-5729
Quinn, J. M., Tam, S., Sims, N. A., Saleh, H., McGregor, N. E., Poulton, I. J., Scott, J. W., Gillespie, M. T., Kemp, B. E., van Denderen, B. J. (2010). Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function. FASEB Journal. 24, 275-285
Saleh, H., Eeles, D., Hodge, J. M., Nicholson, G. C., Gu, R., Pompolo, S., Gillespie M. T. and Quinn, J.M. (2011) Interleukin-33, a target of parathyroid hormone and oncostatin M, increases osteoblastic matrix mineral deposition and inhibits osteoclast formation in vitro. Endocrinology. 152, 1911-1922
van der Kraan, A.G.J., Chai, R.C.C., Singh, P.P., Lang, B.J., Xu, J., Gillespie, M.T., Price, J.T. and Quinn, J.M.W. (2013). HSP90 inhibitors enhance differentiation and Microphthalmia transcription factor (MITF) activity in osteoclast progenitors. Biochemical Journal. 451, 235-244.
Wong, P., Fuller, P.J., Gillespie, M.T., Kartsogiannis, V., Strauss, B.J., Bowden, D. and Milat, F. (2013). Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures. Osteoporosis International. 24, 1965-1971