Dr Simon Chu, OCRF Witchery Research Fellow

Dr Simon Chu completed his PhD at Prince Henry’s Institute of Medical Research (now Hudson Institute of Medical Research) in 2005. His studies focused on the roles of the estrogen receptor in the pathogenesis of a subset of ovarian tumours, those of the granulosa cells, and in particular, the impact that molecular signalling pathways of the cell have on the activities of this receptor. After gaining his PhD, Dr Chu continued his work at PHI, examining the consequences of blocking these pathways using new therapeutic compounds to explore whether this might lead to a new chemotherapeutic approach to treating this disease.

In 2007, Dr Chu took up a postdoctoral position at the Pasteur Institute in Cambodia, where he helped develop a new molecular technique to investigate the incidence of exposure to avian influenza in the human population in that country.

On his return to Australia in 2009, Dr Chu re-joined PHI, now Hudson Institute. His work continued to focus on the underlying causes of the less common type of ovarian cancer, granulosa cell tumours, as well as the more common type, epithelial cancer. He established his own research group, Hormone Cancer Therapeutics, in 2018 and is currently investigating an exciting potential therapeutic option for treating these cancers, using a combination treatment that targets two important biological pathways in the cancer cells. This presents a new targeted therapy for the treatment of ovarian cancers.

Dr Chu’s research continues to be funded by the Ovarian Cancer Research Foundation, which is the leading funder of ovarian cancer research in Australia.

Expertise

  • molecular endocrinology
  • molecular and cellular biology
  • ovarian cancer
  • biochemistry
  • cell culture techniques
  • microarrays
  • laser-capture microscopy

Selected publications

  • Leung DTH, Chu S (2018) Measurement of Oxidative Stress: Mitochondrial Function Using the Seahorse System. Methods in Molecular Biology 1710:285-293

  • Fuller PJ, Leung D, Chu S (2017) Genetics and genomics of ovarian sex cord-stromal tumors. Clinical Genetics 91(2):285-291 [Review]

  • Alexiadis M, Chu S, Leung D, Gould JA, Jobling T, Fuller PJ (2016) Transcriptomic analysis of stage 1 versus advanced adult granulosa cell tumors. Oncotarget 7(12):14207-14219

  • Leung DTH, Fuller PJ, Chu S (2016) Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors. The International Journal of Biochemistry & Cell Biology 72:51-54 [Review]