Dr Ann Drummond

Dr Drummond completed her PhD studies in the area of testicular physiology. Her first appointment as an Assistant Lecturer in the Department of Biochemistry at Monash University combined teaching and research and it was during this period that her research focus turned to regulation of ovarian function. In 1994, she joined Prince Henry’s Institute (PHI) and since this time has pursued the roles of oestrogen and transforming growth factor-beta superfamily members in regulating ovarian follicle development.

Her current research focuses on the regulation of folliculogenesis with an emphasis on local control mechanisms. The results of these studies will lead to a better understanding of and treatments for infertility, premature menopause and ovarian cancer and facilitate the development of new contraceptives.

Dr. Drummond’s expertise is in the molecular assessment of the ovary, in vivo models of folliculogenesis

Service to the Scientific Community:

  • Editorial board, Journal of Endocrinology
  • Editorial board, Reproduction

Collaborators:

Dr. Simon Chu,Hudson Institute of Medical Research, OCRF L’Oreal Paris Research Fellow
Professor John Funder, Hudson Institute of Medical Research
Professor Tim Cole, Biochemistry, Monash Univeersity
Associate Professor Tom Jobling, Gynaecology Oncology, Monash Health
Professor John Katzenellenbogen, Professor Chemistry, University of Illinois, USA
Professor Christine Clarke, Westmead Hospital
Professor Martin Matzuk, Baylor College of Medicine, USA
Professor Michael Karin, University of California, San Diego, USA
Dr. Jane Visvader, Walter & Eliza Hall Institute

Selected publications

  • Rosairo, D., Findlay, J.K. and Drummond, A.E. The effects of FSH and Activin A on follicle development in vitro. Reproduction, 143:221-229, 2012.

  • Liew, J., Sarraj, M., Drummond, A.E. and Findlay, J.K. Estrogen-dependent gene expression in the ovary. PLoS One 6:e14672, 2011.

  • Liew, J., Drummond, A.E., Jones, M.M.E. and Findlay, J.K. The lack of estrogen and excess luteinising hormone are responsible for the female ArKO mouse phenotype. Molecular & Cellular Endocrinology 327:56-64, 2010.

  • Bowden, M.A., Drummond, A.E., Fuller, P.J., Salamonsen, L.A. Findlay, J.K. and Nie, G. High temperature requirement factor A3 (Htra3); a novel serine protease and its potential role in ovarian function and ovarian cancers. Molecular & Cellular Endocrinology 327:13-18, 2010.

  • Bowden, M.A., Drummond, A.E., Salamonsen, L.A., Findlay, J.K. and Nie, G. Evolutionary conservation of mammalian Htra3 and its developmental regulation in the rat ovary. Journal of Experimental Zoology 312:701-713, 2009.

  • Rosairo D,  Kuyznierewicz, I., Findlay J.K. and Drummond A.E. Transforming growth factor-β: its role in ovarian follicle development. Reproduction 136:799-809.2008

  • Drummond A.E., Tellbach M., Dyson M. and Findlay J.K. Fibroblast growth factor-9, a male sex determining factor, identified in the ovary.   Endocrinology, 148:3711-3721, 2007.

  • Drummond A. and Findlay JK.  Focus on TGF-beta signalling.  Editorial: Reproduction 132, 177-178, 2006.

  • Drummond A.E. The role of steroids in follicular growth. Reprod. Biol. Endocrinol. 4:16, 2006.

  • Drummond A.E. TGF-beta signalling in the development of ovarian function. Cell and Tiss. Res. 322: 107-115, 2005.

  • Drummond AE, Dyson M, Le MT, Ethier J-F and Findlay JK.  Ovarian follicle populations of the rat express TGF-beta signalling pathways.  Molecular and Cellular Endocrinology 202, 53-57, 2003.

  • Kate Lakoski Loveland, Marilyn Bakker, Terri Meehan, Elizabeth Christy, Viktoria von Schönfeldt, Ann Drummond, and David de Kretser Expression of Bambi is widespread in juvenile and adult rat tissues and regulated in male germ cells. Endocrinology 144(9):4180-4186, 2003.

  • Jones, R.L., Salamonsen, L.A., Zhao, Y.C., Ethier, J-F., Drummond, A.E. and Findlay J.K. Expression of activin receptors, follistatin and betaglycan by human stromal cells: evidence for a role for activins during decidualisation. Mol. Human Reprod. 8: 363-374, 2002.

  • Britt KL, Kerr J, O’Donnell L, Jones MEE, Drummond AE, Davis SR, Simpson ER and Findlay JK.  Estrogen regulates development of the somatic cell phenotype in the eutherian ovary.  FASEB J 16:1389-1397, 2002.

  • Drummond AE, Le MT, Ethier J-F and Findlay JK.  Expression and localization of activin receptors, Smads and betaglycan to the postnatal rat ovary.  Endocrinology 143: 1423-1433, 2002.

  • Findlay JK, Drummond AE, Dyson ML, Baillie AJ, Robertson DM. and Ethier J-F. Recruitment and development of the preovulatory follicle; the roles of the transforming growth factor-beta superfamily.  Molecular & Cellular Endocrinology 191:35-43, 2002.

  • Drummond AE, Britt KL, Dyson M, Jones MEE, Kerr JB, O’Donnell L, Simpson ER and Findlay JK.  Ovarian steroid receptors and their role in ovarian function.  Molecular and Cellular Endocrinology 191:27-33, 2002.

  • Britt, K.L., Drummond, A.E., Cox, V.A., Dyson, M., Wreford, N.G., Jones, M.E.E., Simpson, E.R. and Findlay, J.K. An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene. Endocrinology 141:2614-2623, 2000.

  • Drummond, A.E., Dyson, M., Thean, E., Groome, N.P., Robertson, D.M., Findlay, J.K. Temporal and hormonal regulation of inhibin protein and subunit mRNA expression by post-natal and immature rat ovaries. Journal of Endocrinology 166:339-354, 2000.