Dr Fiona Cousins

Dr Fiona Cousins is a post-doctoral researcher within the Endometrial Stem Cells Group at Hudson Institute. She is researching the role of stem/progenitor cells in the repair and regeneration of the endometrium and in the pathology of endometrial diseases including endometriosis.

Her research projects are focused on finding a role for stem/progenitor cells in the regenerating endometrium, and investigating the requirement for Notch and Hedgehog signalling in the endometrial stem/progenitor populations that cause endometriosis.

After completing a Bachelor of Science (Hons) in Reproductive Biology in 2007 at The University of Edinburgh, Dr Cousins worked for bio-manufacturer Alba Bioscience (Quotient) before pursuing a Master of Science degree in Biomedical Sciences at Edinburgh Napier University in 2009.

From 2010-2014, Dr Cousins completed her PhD under the supervision of Professors Philippa Saunders and Hilary Critchley at The University of Edinburgh. Her project focused on delineating the mechanisms that contribute to the restoration of endometrial integrity following menstruation. During her PhD, Dr Cousins was also part of a group that developed an animal model for the study of endometriosis, closely mimicking the human disease. Dr Cousins undertook her first post-doctoral position with Professor Saunders from 2014-2015, exploring the inflammatory environment of the endometrium during post-menstrual repair.

In 2015 Dr Cousins was recruited to The Ritchie Centre under the supervision of Associate Professor Caroline Gargett to continue her work on endometrial regeneration. Dr Cousins’ main research interests are in endometrial function and dysfunction and how the latter may contribute to endometrial pathologies including endometriosis, adenomyosis or heavy menstrual bleeding.

 

Selected publications

  • Cousins FL*, Kirkwood PM*, Saunders PTK, Gibson DA. (2016). Evidence for a dynamic role for mononuclear phagocytes in endometrial repair and remodelling. Scientific Reports: 6:36748 doi: 10.1038/srep36748. *Authors contributed equally to this work.

  • Simitsidellis I, Gibson DA, Cousins FL, Esnal-Zufiaurre A, Saunders PT. (2016) A role for androgens in epithelial proliferation and formation of glands in the mouse uterus. Endocrinology: 157(5):2116-28.

  • Gibson DA, Simitsidellis I, Cousins FL, Critchley HOD, Saunders PTK. (2016) Intracrine androgens enhance decidualization and modulate expression of human endometrial receptivity genes. Scientific Reports: 6:19970.

  • Cousins FL, Murray AA, Scanlon JP, Saunders PTK. (2016) Hypoxyprobe reveals dynamic and spatial and temporal change in hypoxia in a mouse model of endometrial breakdown and repair. BMC Research Notes: 9:30.

  • Greaves E, Cousins FL, Murray A, Esnal-Zufiaurre A, Fassbender A, Horne AW, Saunders PTK. (2014) A Novel Mouse Model of Endometriosis Mimics Human Phenotype and Reveals Insights into the Inflammatory Contribution of Shed Endometrium. American Journal of Pathology: 184: 1930-1939.

  • Cousins FL, Murray A, Esnal A, Gibson DA, Critchley HOD, Saunders PTK. (2014) Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity During Menstruation. PLoS ONE 9(1): e86378. doi:10.1371/journal.pone.0086378