Dr James Deane, Senior Research Fellow

Biography

Dr James Deane completed his PhD at The University of Melbourne studying cell biology and subsequently undertook his postdoctoral training at Yale University (USA), using model organisms to identify processes involved in human health and disease. On returning to Australia, Dr Deane worked at Monash University studying renal regeneration and immunology and joined The Ritchie Centre at Hudson Institute in 2012.

Dr Deane’s studies at Hudson Institute focus on the cell biology underlying the regenerative capacity of the endometrium (the lining of the uterus) and its role in fertility and disease. He is examining the role of endometrial stem/progenitor cells during endometrial regeneration. A key aim of this work is to understand how improper regulation of endometrial stem/progenitor cells might cause endometriosis, a common condition where the endometrium escapes the uterus and causes painful growths on other organs.

Dr Deane has published 43 scientific research and review articles, leads a study on mechanisms of lesion growth in endometriosis funded by Ferring Pharmaceuticals, and is a co-Chief investigator on a National Health and Medical Research Council project examining stem/progenitor cells in endometrial regeneration.

Selected publications

  • Darzi S, Werkmeister JA, Deane JA, Gargett CE. Identification and Characterization of Human Endometrial Mesenchymal Stem/Stromal Cells and Their Potential for Cellular Therapy. Stem Cells Transl Med. 2016; 5(9):1127-32.

  • Deane JA, Ong YR, Cain JE, Jayasekara WS, Tiwari A, Carlone DL, Watkins DN, Breault DT, Gargett CE. The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. Mol Hum Reprod. 2016; 22(4):272-84.

  • Gargett CE, Schwab KE, Deane JA. Endometrial stem/progenitor cells: the first 10 years. Hum Reprod Update. 2016; 22(2):137-63.

  • Gurung S, Deane JA, Masuda H, Maruyama T, Gargett CE. Stem Cells in Endometrial Physiology. Semin Reprod Med. 2015; 33(5):326-32.

  • Letouzey V, Tan KS, Deane JA, Ulrich D, Gurung S, Ong YR, Gargett CE. Isolation and characterisation of mesenchymal stem/stromal cells in the ovine endometrium. PLoS One. 2015; 18;10(5):e0127531.

  • Ulrich D, Tan KS, Deane J, Schwab K, Cheong A, Rosamilia A, Gargett CE. Mesenchymal stem/stromal cells in post-menopausal endometrium. Hum Reprod. 2014; 29(9):1895-905.

  • Deane JA, Gualano RC, Gargett CE. Regenerating endometrium from stem/progenitor cells: is it abnormal in endometriosis, Asherman’s syndrome and infertility? Curr Opin Obstet Gynecol. 2013; 25(3):193-200.

  • Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D. BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci U S A. 2015;112(5):1535-40.