Professor Eva Dimitriadis, NHMRC Senior Research Fellow

Biography

After obtaining her Bachelor of Science in Melbourne, Professor Eva Dimitriadis gained eight years experience as a research assistant in Melbourne, Munich and Dublin before completing her PhD studies at Trinity College Dublin, Ireland. She undertook post-doctoral studies at the University of Dublin before returning to Australia to undertake research in reproductive biology at Prince Henry’s Institute, now Hudson Institute of Medical Research.

Prof Dimitriadis has a passion for understanding infertility, the factors that contribute to making the endometrium receptive to an implanting embryo and endometrial-trophoblast interactions during implantation. Her research program includes investigating non-invasive biomarkers of implantation potential. She has a strong focus on microRNA regulation of these processes and investigating novel sustained release targeted delivery options. A number of her projects have a clinical translational focus, and have moved into pre-clinical trials.

Prof Dimitriadis also has a strong interest in developing new non-hormonal contraceptives that also prevent sexually transmitted diseases and the development of novel treatments for endometrial cancer.

Prof Dimitriadis has international, national and industry collaborations including Monash IVF, the Walter and Eliza Hall Institute of Medical Research, Monash University, University of Melbourne, University of Tokyo, Commonwealth Serum Laboratories and the Karolinska Institutet in Sweden.

Selected publications

  • Winship AL, Sorby K, Correia J, Rainczuk A, Yap J, Dimitriadis E (2017) Interleukin-11 up-regulates endoplasmic reticulum stress induced target, PDIA4 in human first trimester placenta and in vivo in mice.  Placenta, 53:92-100.

  • Van Sinderen M, Oyanedel J, Menkhorst E, Cuman C, Rainczuk K, Winship A, Salamonsen LA, Edgell TA, Dimitriadis E (2017) Soluble Delta-like ligand 1 alters human endometiral epithelial cell adhesive capacity.  Reproduction, Fertility and Development 29:694-702.

  • Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Görg B, Häussinger D, Lokau J, Floss DM, Piekorz R, Dimitriadis E, Garbers C, Scheller J. (2016) Transcytosis of IL-11 and Apical Redirection of gp130 is mediated by IL-11a receptor. Cell Reports 16(4):1067-1081.

  • Evans, J, Salamonsen, LA, Winship, A, Menkhorst, E, Nie, G, Gargett, C, Dimitriadis, E (2016)  Fertile ground:  human endometrial programming and lessons in health and disease.  Nature Reviews Endocrinology 12(11):654-66.

  • Winship, AL, Van Sinderen, M, Donoghue, J, Rainczuk, K, Dimitriadis, E (2016) Targeting Interleukin-11 receptor-a impairs human endometrial cancer cell proliferation and invasion in vitro and reduces tumour growth and metastasis in vivoMol Cancer Ther. 15(4):720-730.

  • Winship AL, Koga K, Menkhorst E, Van Sinderen M, Rainczuk K, Nagai M, Cuman C, Yap J, Zhang JG, Simmons D, Young MJ, Dimitriadis E (2015) Interleukin-11 alters placentation and causes preeclampsia features in mice. Proc Natl Acad Sci 112(52):15928-15933.

  • Cuman C, Van Sinderen M, Gantier MP, Rainczuk K, Sorby K, Rombauts L, Osianlis T, Dimitriadis E (2015) Human blastocyst secreted microRNA regulate endometrial epithelial cell adhesion.  EBioMedicine 2(10):1528-1535.

  • Winship, A, Correia, J, Krishnan, T, Menkhorst, E, Cuman, C, Zhang, JG, Nicola, NA, Dimitriadis, E (2015) Blocking endogenous leukemia inhibitory factor during placental development in mice leads to abnormal placentation and pregnancy loss.  Sci Rep 5:13237.

  • Menkhorst, E, Koga, K, Van Sinderen, M, Dimitriadis, E (2014) Galectin-7 serum levels are altered prior to the onset of pre-eclampsia.  Placenta 35(4):281-285.

  • Cuman C, Menkhorst EM, Rombauts LJ, Holden S, Webster D, Bilandzic M, Osianlis T, Dimitriadis E (2013) Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to IVF success. Hum Reprod 28(5):1161-1171.

  • Menkhorst EM, Lane N, Winship AL, Li P, Yap J, Meehan K, Rainczuk A, Stephens A, Dimitriadis E (2012) Decidual-secreted factors alter invasive trophoblast membrane and secreted proteins implying a role for decidual cell regulation of placentation. PLoS One 7(2):e31418.

  • Menkhorst E, Zhang J-G, Sims NA, Morgan PO, Soo P, Poulton IJ, Metcalf D, Alexandrou E, Gresle M, Salamonsen LA, Buzkueven H4, Nicola NA, Dimitriadis E (2011) Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice. PLoS One 6(5):e19665.

  • Marwood M, Visser K, Salamonsen LA, Dimitriadis E (2009) Interleukin 11 and leukaemia inhibitory factor regulate the adhesion of endometrial epithelial cells: implications in fertility regulation. Endocrinology 150:2915-2923.

  • White CA, Zhang J-G, Salamonsen LA, Baca M, Fairlie WD, Metcalf D, Nicola NA, Robb L, Dimitriadis E (2007) Blocking leukemia inhibitory factor action in the uterus using a novel PEGylated antagonist prevents implantation: a new non-hormonal contraceptive strategy. Proc Natl Acad Sci USA 104(49):19357-19362.