Associate Professor Flora Wong, NHMRC Early Career Clinical Research Fellow

Biography

Associate Professor Flora Wong is a Consultant Neonatologist at Monash Newborn, with a joint appointment as Senior Research Fellow at the Department of Paediatrics, Monash University and The Ritchie Centre, Hudson Institute of Medical Research. A/Prof Wong graduated from the University of Melbourne, receiving her PhD on ‘New bedside techniques utilising near infrared spectroscopy (NIRS) in preterm infants’ in 2009. She has been awarded the NHMRC Health Professional Research Fellowship to continue her part-time research commitment. Since 2010, A/Prof Wong has received >$2.7M of competitive research funding from NHMRC and philanthropic bodies.

Her research interests are in newborn cerebral pathophysiology, cerebral blood flow and oxygenation in relation to brain injury in newborn infants undergoing intensive care. Her projects aim to investigate the mechanisms of newborn brain injury, development of cotside monitoring and neuroprotective strategies. She has expertise in the application of NIRS to examine the cerebral haemodynamics, and has pioneered research utilising a technique called Spatially Resolved Spectroscopy in Australia. Her publications demonstrate a strategic set of studies that work towards the identification of circulatory factors which contribute to neonatal brain injury. Translational research is an important theme of her projects, involving complementary experimental studies in preclinical models and clinical studies in preterm infants to examine cerebral haemodynamics.

Selected publications

  • Edwards A, Veldman A, Nitsos I, Chan Y, Brew N, Teoh M, Menahem S, Schranz D, and Wong FY. A percutaneous fetal cardiac catheterization technique for pulmonary valvuloplasty and valvulotomy in a mid-gestation lamb model. Prenatal diagnosis. 2014. Epub 2014/08/27. (IF 2.514)

  • Fyfe KL, Yiallourou SR, Wong FY, Odoi A, Walker AM, Horne RS. Cerebral Oxygenation in Preterm Infants. Pediatrics. 2014. Epub 2014/08/27. (IF 5.297)

  • Brew N, Walker D, Wong FY. Cerebral Vascular Regulation and Brain Injury in Preterm Infants. Am J Physiol Regul Integr Comp Physiol March 2014, Epub 2014/03/22 (IF 3.284)

  • Olhager E, Nold C, Mandar J, Doery J, Samarasinghe T, Walker AM, Wong FY. Dopamine values in cerebrospinal fluid in preterm lambs given dopamine intravenously. Acta Paediatrica 2014;103:337-42. (IF 1.974)

  • Wong FY, Yiallourou SR, Odoi A, Browne P, Walker AM, Horne RSC. Cerebrovascular Control Is Altered In Healthy Term Infants When They Sleep Prone. Sleep 2013;36:1911-1918 (IF 5.05)

  • Edwards E, Menahem S, Nitsos I, Chan Y, Veldman A, Schranz D, Wong FY. Fetal Cardiac Catheterization using a Percutaneous Transhepatic Access Technique: Preliminary Experience in a Lamb Model. Ultrasound in Obstetrics and Gynaecology 2013;42:58-63. (IF 3.557)

  • Wong FY, Silas R, Hew S, Samarasinghe T, Walker AM. Cerebral Oxygenation Is Highly Sensitive to Blood Pressure Variability in Sick Preterm Infants. PLoS ONE 2012; 7(8): e43165. doi:10.1371/journal.pone.0043165 (IF 4.41)

  • Polglase GR, Miller SL, Barton SK, Baburamani AA, Wong FY, Aridas J, Gill AW, Moss TJW, Tolcos M, Kluckow M, Hooper SB. Initiation of resuscitation with high tidal volumes causes cerebral hemodynamic disturbance, brain inflammation and injury in preterm lambs. PLoS ONE 2012; 7(6): e39535. doi:10.1371/journal.pone.0039535 (IF 4.41)

  • Wong FY, Witcombe NB, Yiallourou SR, Yorkston SM, Walker AM, Horne RSC. Cerebral oxygenation is depressed during sleep in healthy term infants when they sleep prone. Pediatrics 2011;127:e558-565. (IF 4.79)

  • Wong FY, Alexiou T, Samarasinghe T, Brodecky V, Walker AM. Cerebral arterial and venous contributions to tissue oxygenation index measured using spatially resolved spectroscopy in newborn lambs. Anesthesiology 2010:113(6):1385-91. (IF 5.35)

  • Veldman A, Santamaria-Araujo JA, Sollazzo S, Pitt J, Gianello R, Lee JY, Wong FY, Ramsden CA, Reiss J, Cook I, Fairweather J, Schwarz G. Successful Treatment of Molybdenum Cofactor Deficiency Type A with Cyclic Pyranopterin Monophospate (cPMP). Pediatrics 2010:125(5): e1249-e1254.(IF4.79, citation 50)

  • Wong FY, Barfield CP, Horne, RSC, Walker AM. Dopamine therapy promotes cerebral flow-metabolism coupling in preterm infants. Intensive Care Medicine 2009:35:1777-82.(IF 5.17)

  • Wong FY, Nakamura M, Alexiou T, Brodecky V, Walker AM. Tissue oxygenation index measured using spatially resolved spectroscopy correlates with changes in cerebral blood flow in newborn lambs. Intensive Care Med 2009;35:1464-70. (IF 5.17)

  • Wong FY, Leung T, Austin T, Wilkinson M, Meek J, Wyatt J, Walker AM. Impaired Dynamic autoregulation in preterm infants identified using spatially resolved spectroscopy. Pediatrics 2008;121(3):e604-611 (IF 4.79, citation 81)

  • Wong FY, Barfield CP, Campbell L, Brodecky V, Walker AM. Validation of cerebral oxygenation measured using near-infrared spectroscopy and partial jugular venous occlusion in the newborn lamb. Journal of cerebral blood flow and metabolism 2008;28(1):74-80 (IF 5.74, citation 4)