Dr Graeme Polglase, NHMRC Biomedical CDF and Rebecca Cooper Medical Foundation Research Fellow

Biography

An internationally recognised physiologist, Dr Polglase is a leading authority on the role of pulmonary, cardiovascular, and cerebral circulation in organ inflammation and injury in preterm and compromised infants. A Monash University Graduate, he completed his PhD in 2005. Dr Polglase was recruited to join the Department of Women’s and Infants’ Health, the University of Western Australia, Perth, WA, which was running the largest perinatal ovine research program in the world. Following his promotion to manager in 2008, he took over primary responsibility for running all animal studies. In 2010, Dr Polglase joined The Ritchie Centre where he established the Perinatal Transition Research Group in 2011 to influence clinical practice in the management of preterm and compromised infant care. Translation of his findings continues to improve treatment outcomes as evidenced by his publications cited in Australian, European, and International resuscitation guidelines, and multiple invitations to speak at national and international clinical meetings.

Recognised by the NHMRC with Early Career and Career Development Fellowships, Dr Polglase was also the inaugural recipient of the Rebecca L. Cooper Medical Research Fellowship, and received significant funding from the NIH. He has also received funding from the National Heart Foundation of Australia, Cerebral Palsy Alliance, and Financial Markets for Children.

Premature birth is the single greatest cause of neonatal morbidity and mortality. Dr Polglase is working to improve the respiratory, cardiovascular, and neurological outcomes of infants born preterm. His findings continue to expand the understanding of how key events during fetal development, birth, and post-delivery influence the pulmonary, cardiovascular and cerebral systems of preterm babies. He hopes this work will reduce the incidence of organ inflammation and injury, in order to improve outcomes for some of our tiniest patients.

Selected publications

  • Polglase G.R., Miller S. L., Barton S. K., Kluckow M.,Gill A.W.,Hooper S.B. and Tolcos M. Respiratory support for premature neonates in the delivery room: potential effects on cardiovascular function and brain injury. Invited Review. Pediatr Res. 2014 Jun;75(6):682-8.

  • Skiold B., Hooper S.B., Wu Q., Hooper S.B., Davis P.G., McIntyre R.2, Tolcos M., Pearson J., Vreys R., Egan G.F., Barton S.K., Cheong J.L.Y. Polglase G.R. Early detection of ventilation-induced brain injury using magnetic resonance spectroscopy and diffusion tensor imaging: an in vivo study in preterm lambs. PLoS One. 2014 Apr 23;9(4):e95804.

  • Polglase G.R., Barton S.K., Melville J.M., Zahra V., Wallace M.J., Siew M.L., Tolcos M. and Moss T.J.M. Prophylactic erythropoietin exacerbates ventilation-induced lung inflammation and injury in preterm lambs. J Physiol. 2014 May 1;592(Pt 9):1993-2002.

  • Bhatt, S., Allison, B.J., Wallace, E.M., Crossley K.C., Gill A.W., Kluckow M., te Pas A.B., Morley, C.J., Polglase, G.R.*, and Hooper S.B*. Ventilation onset before umbilical cord clamping improves cardiovascular function at birth in preterm lambs.J Physiol. 2013 Apr 15;591(Pt 8):2113-26.

  • Polglase G.R., Tingay D., Bhatia R., Berry C., Kopotic R., Kopotic C., Song Y., Szyld E., Jobe A.H. and Pillow J.J. Pressure- versus volume-limited sustained inflations: recruiting the preterm lung. BMC Pediatr. 2014 Feb 15;14:43.

  • Tare M., Bensley J., Moss T.J.M., Lingwood BE., Kim MY., Barton S.K., Kluckow M., Gill A.W., De Matteo R., Harding R., Black MJ., Parkington H.C. and Polglase G.R., Cardiac function of preterm lambs is compromised by intrauterine inflammation. In Press Clinical Science (London), 2014.

  • Galinsky R., Hooper S.B. Wallace M.J., Westover A. Black M.J., Moss T.J.M. and Polglase G.R. Intrauterine inflammation alters cardiopulmonary and cerebral haemodynamics at birth in fetal sheep. J Physiol. 2013 Apr 15;591(Pt 8):2127-37. Impact Factor: 4.88. Citations:0.

  • Polglase G.R. and Hooper S.B. Role of Intra-luminal Pressure in Regulating Pulmonary Blood Flow in the Fetus and After Birth. Current Pediatric Reviews 2006, 2(4): 287-299. No Impact Factor. Citations: 4.

  • Andersen C.C., Pillow J.J., Gill A.W., Allison B.J., Nitsos I., Kluckow M. and Polglase G.R. The critical oxygen threshold in the brain of ventilated preterm lambs exposed to intrauterine inflammation. J Appl Physiol. 2011 Sep;111(3):775-81. Impact Factor: 3.658.

  • Polglase G.R., Miller S.L., Barton S.K., Baburamani A.A., Wong F.Y., Aridas J., Gill A.W., Moss T.J.M., Kluckow M. and Hooper S.B. Initiation of resuscitation with high tidal volumes causes cerebral hemodynamic disturbance, brain inflammation and injury in preterm lambs. PLoS One. 2012;7(6):e39535.

  • PolglaseG.R., Hooper S.B., Gill A.W., Allison B.J., Crossley K.J., Moss T.J.M., Nitsos I., Pillow J.J. and Kluckow M. Intrauterine inflammation causes pulmonary hypertension and cardiovascular sequelae in preterm lambs. Journal of Applied Physiology. 2010 Jun;108(6):1757-65.

  • Polglase G.R., Hooper S.B., Gill A.W., Allison B.J., McLean C.J., Nitsos I., Pillow J.J. and Kluckow M. Cardiovascular and pulmonary consequences of airway recruitment in preterm lambs. Journal of Applied Physiology 2009. 106(4) 1347-55.

  • Polglase G.R., Hillman N., Pillow J.J. Cheah F., Nitsos I., Moss T.J.M.,Kramer, B. W., Ikegami, M., Kallapur, S. G. & Jobe A.H. Positive End-Expiratory Pressure and Tidal Volume During Initial Ventilation of Preterm Lambs. Pediatric Research 2008, Nov;64(5):517-22.

  • Polglase G.R., Hillman N.H., Ball M.K., Kramer B.W., Kallapur S.G., Jobe A.H. & Pillow J.J. Lung and Systemic Inflammation in Preterm Lambs on CPAP or Conventional Ventilation. Pediatric Research 2008. Nov;64(5):517-22.

  • Polglase G.R., Nitsos I. Jobe A.H., Newnham J.P. and Moss T.J.M. Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs. Pediatric Research 2007, Jul;62(1):32-36.