Dr Niamh Mangan, Fielding Foundation Fellow

Biography

Dr Niamh Mangan is a research scientist and emerging expert in immunology of infections and inflammation. After completing her PhD at Trinity College Dublin, Ireland under the supervision of Professor Padraic Fallon, Dr Mangan travelled to Australia where she undertook postdoctoral training with Professor Paul Hertzog from 2008.

In 2010, Dr Mangan was awarded a prestigious Australian Research Council Fellowship, as well as a New Investigator award by the National Health and Medical Research Council.

Her research interests lie primarily in understanding cellular mechanisms of modulation and suppression of the immune response in infections and inflammation. Her current research examines the role of interferon, cytokine and receptor signalling in immune regulation, in particular characterising the novel cytokine interferon epsilon (IFNε) in the regulation of mucosal immune responses.

Dr Mangan was the Chair of the Hudson Institute Early Career Researcher Committee and has sat on conference-organising committees for the Victorian Infection and Immunity Network (2015) and Cytokines 2014, a major international conference. She has served on numerous other committees in the Hudson Institute of Medical Research, including the Monash Animal Ethics Committee (2011-2014).

Selected publications

  • Cottle DL, Ursino GM, Ip SC, Jones LK, Ditommaso T, Hacking DF, Mangan NE, Mellett NA, Henley KJ, Sviridov D, Nold-Petry CA, Nold MF, Meikle PJ, Kile BT, Smyth IM (2015) Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Hum Mol Genet 24:436-449.

  • Eid SG, Mangan NE, Hertzog PJ, Mak J (2015) Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses. Clin Transl Immunol 4:e43.

  • Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF (2015) IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction. Nat Immunol 16:354-365.

  • Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O’Neill LA (2014) The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10. J Biol Chem 289:4316-4325.

  • Samarajiwa SA, Mangan NE, Hardy MP, Najdovska M, Dubach D, Braniff SJ, Owczarek CM, Hertzog PJ (2014) Soluble IFN receptor potentiates in vivo type I IFN signaling and exacerbates TLR4-mediated septic shock. J Immunol192:4425-4435.

  • Stifter SA, Gould JA, Mangan NE, Reid HH, Rossjohn J, Hertzog PJ, de Weerd NA (2014) Purification and biological characterization of soluble, recombinant mouse IFNβ expressed in insect cells. Protein Expr Purif 94:7-14.

  • de Weerd NA, Vivian JP, Nguyen TK, Mangan NE, Gould JA, Braniff SJ, Zaker-Tabrizi L, Fung KY, Forster SC, Beddoe T, Reid HH, Rossjohn J, Hertzog PJ (2013) Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1. Nat Immunol 14:901-907.

  • Fung KY*, Mangan NE*, Cumming H, Horvat JC, Mayall JR, Stifter SA, De Weerd N, Roisman LC, Rossjohn J, Robertson SA, Schjenken JE, Parker B, Gargett CE, Nguyen HP, Carr DJ, Hansbro PM, Hertzog PJ (2013) Interferon-ε protects the female reproductive tract from viral and bacterial infection. Science 339:1088-1092. (*joint first authors)

  • Nold MF, Mangan NE, Rudloff I, Cho SX, Shariatian N, Samarasinghe TD, Skuza EM, Pedersen J, Veldman A, Berger PJ, Nold-Petry CA (2013) Interleukin-1 receptor antagonist prevents murine bronchopulmonary dysplasia induced by perinatal inflammation and hyperoxia. Proc Natl Acad Sci USA 110:14384-14389.

  • Bidwell BN, Slaney CY, Withana NP, Forster S, Cao Y, Loi S, Andrews D, Mikeska T, Mangan NE, Samarajiwa SA, de Weerd NA, Gould J, Argani P, Moller A, Smyth MJ, Anderson RL, Hertzog PJ, Parker BS (2012) Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape. Nat Med 18:1224-1231.