Dr Patrick Western

Biography

Dr Patrick Western is interested in understanding the signalling and epigenetic processes underlying sex-specific establishment of the germ line and the impact of transmitted epigenetic information on the next generation.

After completing his doctoral studies on temperature-dependent sex determination in the American alligator, he moved to the UK to complete postdoctoral training at Cambridge University. Working in Professor Azim Surani’s laboratory at the Wellcome Trust Gurdon Institute, Cambridge University, he studied the reacquisition of pluripotency in differentiated somatic cells and identified novel genes associated with pluripotency in embryonic stem cells and germ cells. In 2003, Dr Western joined the ARC Centre of Excellence in Biotechnology and Development, where he pursued an interest in germ cell development with focus on sex-specific differentiation of germ cells and the molecular and epigenetic regulation of germ cell pluripotency. In 2011, Dr Western established the Germ Cell Development and Epigenetics Group within the Centre for Genetic Diseases at Hudson Institute of Medical Research.

Selected publications

  • Miles DC, Wakeling SI, Stringer JM, van den Bergen JA, Wilhelm D, Sinclair AH, Western PS (2013) Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS One 8:e54606.

  • Stringer JM, Barrand S, Western P (2013) Fine-tuning evolution: germ-line epigenetics and inheritance. Reproduction 146:R37-48.

  • Wakeling SI, Miles DC, Western PS (2013) Identifying disruptors of male germ cell development by small molecule screening in ex vivo gonad cultures. BMC Res Notes 6:168.

  • Miles DC, van den Bergen JA, Wakeling SI, Anderson RB, Sinclair AH, Western PS (2012) The proto-oncogene Ret is required for male foetal germ cell survival. Dev Biol 365:101-109.

  • Miles DC, Western PS (2012) Germ cell sex and cell cycle. Histol Histopathol 27:445-457.

  • Western PS, Ralli RA, Wakeling SI, Lo C, van den Bergen JA, Miles DC, Sinclair AH (2011) Mitotic arrest in teratoma susceptible fetal male germ cells. PLoS One 6:e20736.

  • Miles DC, van den Bergen JA, Sinclair AH, Western PS (2010) Regulation of the female mouse germ cell cycle during entry into meiosis. Cell Cycle 9:408-418.

  • Western PS, van den Bergen JA, Miles DC, Sinclair AH (2010) Male fetal germ cell differentiation involves complex repression of the regulatory network controlling pluripotency. FASEB J 24:3026-3035.

  • van den Bergen JA, Miles DC, Sinclair AH, Western PS (2009) Normalizing gene expression levels in mouse fetal germ cells. Biol Reprod 81:362-370.

  • Western P (2009) Foetal germ cells: striking the balance between pluripotency and differentiation. Int J Dev Biol 53:393-409.

  • Western PS, Miles DC, van den Bergen JA, Burton M, Sinclair AH (2008) Dynamic regulation of mitotic arrest in fetal male germ cells. Stem Cells 26:339-347.

  • Maldonado-Saldivia J, van den Bergen J, Krouskos M, Gilchrist M, Lee C, Li R, Sinclair AH, Surani MA, Western PS (2007) Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line. Stem Cells 25:19-28.

  • Western P, Maldonado-Saldivia J, van den Bergen J, Hajkova P, Saitou M, Barton S, Surani MA (2005) Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2 and differences between human pluripotent cell lines. Stem Cells 23:1436-1442.

  • Byrne JA, Simonsson S, Western PS, Gurdon JB (2003) Nuclei of adult mammalian somatic cells are directly reprogrammed to oct-4 stem cell gene expression by amphibian oocytes. Curr Biol 13:1206-1213.

  • Google Scholar Citations: http://scholar.google.com.au/citations?user=igBeqKUAAAAJ