Dr Sadler is expert in innate immunity. After completing his early research training in microbial genetics at the University of Canterbury and virology at the University of Otago he travelled to the US where he conducted postdoctoral research into host immune responses to microbial pathogens at the Centre for Cancer Biology within the Learner Research Institute. In 2007, Dr Sadler came to Australia where he took up a position as a Senior Research Fellow within the Hudson Institute’s Centre for Cancer Research. He subsequently moved to the Centre for Innate Immunity and Infectious Disease within the same institute. His research group investigates innate immune responses that drive inflammation. Dr Sadler’s research has advanced our knowledge of the regulation of cell signalling pathways that control responses to our environment. His research aims to characterise mechanisms that cause inflammation to be able to identify strategies to curb inflammatory pathologies and ensuing disease.
Yim HCH, Wang D, Yu L, White CL, Faber PW, Williams BRG and Sadler AJ. The kinase activity of PKR represses inflammasome activity. Cell Reports in press 2015.
Sadler AJ et al. The BTB-ZF transcriptional regulator, PLZF (ZBTB16), modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci USA, 112(5):1535-40, 2015.
Sadler AJ et al. The Acetyltransferase HAT1 Moderates the NF-kB Response by Regulating the Transcription Factor PLZF (ZBTB16). Nat. Comm., 13;6:6795, 2015.
Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD and Williams BRG (2009). Promyelocytic Leukemia Zinc Finger protein (ZBTB16) regulates interferon-mediated innate immunity. Immunity 30(6):802-816, 2009.
Yuan X, Yu L, Li J, Xie G, Rong T, Zhang L, Chen J, Meng Q, Irving AT, Wang D, Liu J, Sadler AJ, Williams BRG, Shen L, and Dakang Xu D. ATF3 Suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodelling of the actin cytoskeleton. Cancer Research, 15;73(12):3625-37, 2013.
Irving AT, Wang D, Vasilevski O, Latchoumanin O, Vu D, Kozer N, Clayton AHA, Morimoto H, Xu D, Williams BRG, and Sadler AJ. Regulation of actin dynamics by Protein Kinase R control of Gelsolin enforces basal innate immune defence. Immunity 25;36(5):795-806, 2012.
Sadler AJ, et al. An antiviral response directed by PKR phosphorylation of the RNA helicase A. PLoS Pathogens 5(2):e1000311, 2009.
Sadler AJ and Williams BRG. Interferon-inducible antiviral effectors. Nat Rev Immunol 8 (7): 559-568, 2008.