Dr Sadler is expert in innate immunity. After completing his early research training in microbial genetics at the University of Canterbury and virology at the University of Otago he travelled to the US where he conducted postdoctoral research into host immune responses to microbial pathogens at the Centre for Cancer Biology within the Learner Research Institute. In 2007, Dr Sadler came to Australia where he took up a position as a Senior Research Fellow within the Hudson Institute’s Centre for Cancer Research. He subsequently moved to the Centre for Innate Immunity and Infectious Disease within the same institute. His research group investigates innate immune responses that drive inflammation. Dr Sadler’s research has advanced our knowledge of the regulation of cell signalling pathways that control responses to our environment. His research aims to characterise mechanisms that cause inflammation to be able to identify strategies to curb inflammatory pathologies and ensuing disease.
Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8:559-568.
Sadler AJ, Latchoumanin O, Hawkes D, Mak J, Williams BR (2009) An antiviral response directed by PKR phosphorylation of the RNA helicase A. PLoS Pathog 5:e1000311.
Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR (2009) Promyelocytic Leukemia Zinc Finger protein (ZBTB16) regulates interferon-mediated innate immunity. Immunity 30:802-816.
Irving AT, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton AH, Szczepny A, Morimoto H, Xu D, Williams BR, Sadler AJ (2012) Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defence. Immunity 36:795-806.
Yuan X, Yu L, Li J, Xie G, Rong T, Zhang L, Chen J, Meng Q, Irving AT, Wang D, Liu J, Sadler AJ, Williams BR, Shen L, Xu D (2013) ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton. Cancer Res 73:3625-3637.
Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D (2015) The BTB-ZF transcriptional regulator, PLZF (ZBTB16), modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci USA 112:1535-1540.
Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST, Banerjee A, Mansell AS, Liu JP, Gerondakis S, Williams BR, Xu D (2015) The Acetyltransferase HAT1 Moderates the NF-kB Response by Regulating the Transcription Factor PLZF (ZBTB16). Nat Commun 6:6795.
Yim HC, Wang D, Yu L, White CL, Faber PW, Williams BR, Sadler AJ (2016) The kinase activity of PKR represses inflammasome activity. Cell Res 26:367-379.