Dr Shanti Gurung

Dr Shanti Gurung is a post-doctoral researcher in the Endometrial Remodelling Lab at the Hudson Institute of Medical Research. She is researching the role of human endometrial derived secretomes in embryo implantation in the endometrium. In particular, she is looking at the effect of exosomes and secreted proteins, the main components of secretomes, in the adhesion, implantation and outgrowth of the embryos in the endometrium using in vitro and in vivo animal models.

Dr Gurung is a medical graduate from Nepal. She completed her Bachelor of Medical Science (Hons) in 2011 and from 2012-2017 she completed her PhD under the supervision of Professors Caroline E. Gargett and Jerome A. Werkmeister at Monash University. Dr Gurung’s project focused on culture expansion of endometrial mesenchymal stem cells for management of gynaecological diseases. She found that inhibiting the TGF-βR pathway, the culture-expanded endometrial mesenchymal stem cells could be maintained in an undifferentiated state with similar properties as the primary cells, which are potent cells with properties such as anti-fibrosis, angiogenesis and immunomodulation.

Selected publications

  • Darzi S, Deane JA, Nold CA, Edwards S, Gough DJ, Mukherjee S, Gurung S, Tan KS, Vashi AV, Werkmeister JA, Gargett CE (2018) Endometrial mesenchymal stem/stromal cells modulate the macrophage response to implanted polyamide/gelatin composite mesh in immunocompromised and immunocompetent mice. (Accepted in Sci Rep)

  • Gurung S, Deane JA, Darzi S, Werkmeister JA, Gargett CE (2018) In vivo survival of human endometrial mesenchymal stem cells transplanted under the kidney capsule of immunocompromised mice. Stem Cells Dev 27(1):35-43.

  • Gargett CE, Gurung S (2016) Endometrial mesenchymal stem/stromal cells, their fibroblast progeny in endometriosis and more. Biol Reprod 94(6):129.

  • Gurung S, Werkmeister JA, Gargett CE (2016) Endometrial MSC and tissue engineering for pelvic organ prolapse repair. In The Biology and Therapeutic Application of Mesenchymal Cells. Anderson K, ed.  John Wiley & Sons.

  • Letouzey V, Tan KS, Deane JA, Ulrich D, Gurung S, Ong YR, Gargett C (2015) Isolation and characterisation of mesenchymal stem/stromal cells in the ovine endometrium. PloS One 10(5):e0127531.

  • Gurung S, Deane JA, Masuda H, Maruyama T, Gargett CE (2015) Stem cells in endometrial physiology. Semin Reprod Med 33(5):326-32.

  • Gurung S, Werkmeister JA, Gargett CE (2015) Inhibition of transforming growth factor-beta receptor signaling promotes culture expansion of undifferentiated human endometrial mesenchymal stem/stromal cells. Sci Rep 5:15042.