Professor Vincent Harley, NHMRC Senior Research Fellow

Biography

Professor Vincent Harley leads the Sex Determination and Gonadal Development Research Group in the Centre for Endocrinology and Metabolism. He previously held positions in the UK (Imperial Cancer Research Fund Laboratories, London, and Department of Genetics at Cambridge University) and at the Howard Florey Institute in Melbourne, before joining the Prince Henry’s Institute, now Hudson Institute of Medical Research, in 2000.

Prof Harley’s research focuses on transcription factors and their role in health and disease, with a particular focus on sex determining gene, SRY and its contribution to sex (male) bias in certain neurological disorders, such as Parkinson’s disease, ADHD and schizophrenia. A second research aim is to establish the biological basis for gender identity through genetic analyses of transgender individuals.

His expertise lies in molecular genetics, sex differentiation, organ development and gene regulation.

Selected publications

  • Czech DP, Lee J, Correia J, Loke H, Möller E, Harley VR (2014) Transient neuroprotection by SRY up-regulation in dopamine cells following injury in males. Endocrinology. Apr 7 [Epub] PMID: 24708242

  • Lee, J. and Harley, V. (2012) The male fight-flight response: A result of SRY regulation of   catecholamines? Bioessays.34(6): 545-7

  • Czech, D.P., Lee, J., Sim, H., Parish, C.L., Vilain, E. and Harley, V.R. The human testis determining factor SRY localizes in the substantianigra and regulates multiple components of dopamine synthesis and metabolism. (2012) Journal of Neurochemistry 122(2): 260-271

  • Hare, L., Bernard, P., Sánchez, F.J., Baird, P.N., Vilain, E., Kennedy, T. and Harley, V.R. (2009) Androgen receptor repeat length polymorphism associated with male-to-female transsexualism. Biological Psychiatry65: 93-96

  • Dewing, P., Chiang, C.W.K., Sinchak, K., Sim, H., Fernagut, P.-O., Kelly, S., Chesselet, M.-F., Micevych, P.E., Albrecht, K.H., Harley, V.R. and Vilain, E. (2006) Direct regulation of adult brain function by the male-specific factor SRY. Current Biology 16: 415-420