– Cancer and Innate Immunity
– Developmental and Cancer Biology
– Cancer Drug Discovery
– Genetics and Molecular Pathology
– Leukaemia Research
– Oncogenic Signalling
– Ovarian Cancer Biomarkers
– STAT Cancer Biology
Research > Centre for Cancer Research > STAT Cancer Biology
Research Group Head: Dr Daniel Gough
Intracellular signal transduction pathways affect diverse cell functions such as proliferation, death, differentiation, metabolism, and immune responses. Alterations in these pathways drive many diseases including cancer. The STAT Cancer Biology group focus on defining how the disruption of signalling, through the critical STAT family of proteins, alters the onset and progression of tumours.
The STAT Biology Group uses biochemical, cell biological and genomic approaches to define fundamental biochemical pathways, which engage the STAT proteins and apply this knowledge to mouse models of cancer.
Research themes in The STAT Cancer Biology Group:
Mitochondrial STAT3: In 2009 Dr Gough found that STAT3 enters the mitochondria, and that it is this pool of STAT3 which is critical for tumour growth driven by the Ras family of oncogenes. However, many fundamental questions remain. We use mass-spectrometry, biochemistry and animals models of cancer to address these questions.
STAT3 in Childhood Tumours: STAT3 is over-expressed or activated in many paediatric cancers which often correlates with poor overall and relapse free survival. We use pre-clinical animal models to define the role(s) for STAT3 in the most prevalent and deadly paediatric tumours including those of the brain, blood and bone.
Dr Daniel Gough (Research Group Head)
Dr Daniel Garama
Dr Christine White