Big step toward slowing emphysema

26 September 2022

By Rob Clancy, staff writer

Researchers are closer than ever to being able to turn off the actions of the immune system that damage the lungs – opening up the possibility of slowing emphysema development.

At a glance

Professor Brendan Jenkins works on being able to turn off the actions of the immune system that damage the lungs, opening up the possibility of slowing emphysema development. — *Professor Brendan Jenkins*

Emphysema is a major cause of death worldwide
Hudson Institute showed that inflammasomes promote emphysema development
This could lead to new drug treatments slowing emphysema’s progression

Emphysema is the major debilitating component of the lethal chronic obstructive pulmonary disease (COPD), which was the third leading cause of death worldwide in 2019, causing 3.23 million deaths.

Researchers at Hudson Institute are investigating how uncontrolled activation of the immune system in the lung causes emphysema, and how to prevent it.

Slowing emphysema progress

Professor Brendan Jenkins’ research has revealed that a multiprotein complex of the innate immune system, called inflammasomes, promotes the development of emphysema.

His research, as part of a team comprising Australian, German, Swiss and American researchers, is published in the prestigious journal Procedures of the National Academy of Science (USA).

Prof Jenkins said this opens the possibility of new emphysema treatments targeting the immune system, which could slow emphysema’s progress in the lungs.

Immune-based emphysema therapeutics

“These findings lay the foundation for the future design and clinical application of novel innate immune-based therapeutics against emphysema,” he said.

“It is significant research, because it’s the first to demonstrate a specific pathological role for the AIM2 inflammasome in emphysema, in which we delineate a function for AIM2 in driving alveolar cell death in the lung that is independent of immune cell activity and inflammation.”

Emphysema facts

Emphysema is the major debilitating component of the lethal chronic obstructive pulmonary disease (COPD), which the World Health Organisation says was the third leading cause of death worldwide in 2019.
Together, lung cancer and emphysema claim around 15,000 lives in Australia each year.
Patients with emphysema are at an increased risk (between 25 and 30 per cent) of also developing lung cancer, the most lethal cancer in the world.

Collaborators | University of Melbourne, Monash Health, University Hospital of Geneva, National Cancer Institute (USA), RMIT University, Christian-Albrechts-University (Kiel, Germany).

Funders | National Health and Medical Research Council (NHMRC)