Research group
RNA Biology and Innate Immune Sensing
Biography
Dr Heraud-Farlow’s research is focused on understanding the molecular pathways that underlie rare autoinflammatory disease. Her goal is to harness this knowledge to develop new therapeutics for diseases with an immune or inflammatory component, including viral infection, cancer and autoinflammatory/autoimmune disease.
Dr Heraud-Farlow leads a small team within the RNA biology and innate immune sensing lab. She is an RNA biologist by training and uses animal and cellular models coupled with cutting edge techniques to understand the immune response to RNA, how this goes awry in disease and how this can be targeted for therapy. She has received more than $2.5M in funding as CIA from NHMRC and philanthropic bodies.
Education
| PhD |
University of Vienna |
Austria |
| B. Biomed Sci (Hons) |
University of Melbourne |
Australia |
Awards and fellowships
| 2023-2025 |
NHMRC Ideas Grant (CIA) |
NHMRC |
| 2020-2022 |
NHMRC Ideas Grant (CIA) |
NHMRC |
| 2020-2022 |
Christine Martin Fellow |
5point foundation |
| 2018-2019 |
E.H. Flack Fellow |
|
Affiliations
| Adjunct Research Fellow |
Monash University |
Publication highlights
Hu S*, Heraud-Farlow JE*, Sun T, Liang Z, Goradia A, Taylor S, Walkley CR*,†, Li JB*,†. (2023) ADAR1p150 Prevents MDA5 and PKR Activation via Independent Mechanisms to Protect against Fatal Autoinflammation. Mol Cell 83(21):3869-3884
Liang Z, Goradia, A., Walkley CR*, Heraud-Farlow JE*,†. (2023) Generation of a new Adar1p150-/- mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis. RNA 29(9):1325-1338.
Mendez Ruiz S, Chalk AM, Goradia A, Heraud-Farlow JE*,†, Walkley CR*,†. (2023) Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo. NAR Cancer 5(2): zcad023
Liang Z, Taylor S, Goradia A, Heraud-Farlow JE*,†, Walkley CR*,†. (2023) The most common human ADAR1p150 Za domain mutation P193A is well tolerated in mice. EMBO Reports 24(5):e55835
AM Chalk, S Taylor, JE Heraud-Farlow*, CR Walkley* (2019) The majority of A-to-I RNA editing is not required for mammalian homeostasis. Genome biology 20 (1), 1-14
Heraud-Farlow JE, Chalk AM, Gupte, A, Taylor S, Li JB, Walkley CR (2017) Adenosine-to-Inosine RNA editing by ADAR1 is dispensable for normal murine development once self-recognition by MDA5 is prevented. Genome Biology (18) 1: 166
Sharangdhar T, Sugimoto Y, Heraud‐Farlow JE, Fernández‐Moya SM, Ehses J, Ruiz de los Mozos I, Ule J, Kiebler MA (2017) A retained intron in the 3′‐UTR of Calm3 mRNA mediates its Staufen2‐and activity‐dependent localization to neuronal dendrites. EMBO Rep 18(10):1762-1774
