CRH Reproduction Seminar | Associate Professor Anne Goriely
A/Prof Anne Goriely, MRC Weatherall Institute of Molecular Medicine, Oxford University, UK.
Talk title: ‘Ageing Men, Their Selfish Testes, New Mutations and Congenital Disease’
A/Professor Goriely has focused on understanding genetic mutations in the male germline, particularly the concept of “Selfish Spermatogonial Selection” whereby mutations in key determinants of spermatogonial stem cell self renewal, driving their clonal expansion. These mutations result in production of distinct populations of sperm that transmit specific mutations to offspring and underlie age-related increases in specific pathologies. A/Prof Goriely’s work aims to understand how selfish selection affects genome heterogeneity and how mutation rates are controlled in the male germline to ensure the faithful transmission of genetic material across generations.