Hudson Seminar Series | Professor Ricky Johnstone
Professor Ricky Johnstone PhD, FAHMS, Executive Director Cancer Research Head, The Sir Peter MacCallum Department of Oncology, The University of Melbourne Head, Gene Regulation Lab, will be presenting a seminar titled ‘Targeting transcriptional CDKs in Cancer’.
Professor Ricky Johnstone received his PhD from the University of Melbourne in 1993 and after a postdoc at Harvard Medical School to Melbourne to establish the Gene Regulation Laboratory at the Peter MacCallum Cancer Centre in 2000.
Professor Johnstone is the Executive Director Cancer Research at the Peter MacCallum Cancer Centre overseeing ~700 staff and students and plays a key role in strategic decision making across the organisation.
He has published more than 250 peer-reviewed papers, was awarded an NHMRC Senior Principal Research Fellowship in 2015, and in 2011 was promoted to Full Professor in the Department of Pathology.
Prof Johnstone is an internationally renowned cancer researcher who has utilized genetic mouse models of hemopoietic malignancies and solid tumors to understand the epigenetic and transcriptional changes that underpin tumor onset and progression and to develop new
therapies that target epigenetic and transcriptional regulatory proteins.
The dependency of tumor cells on aberrant gene-expression programs and the reliance on core-transcriptional machinery in these cells has been coined “transcriptional addiction”. In this session Professor Johnstone will focus on transcriptional cyclin-dependent kinases (CDKs) and discuss how dysregulation of the transcription cycle plays an important role in cancer and how their therapeutic targeting provide a framework for the rational therapeutic application
of these agents in oncology.