Epigenetic control mechanisms during the inflammatory response play a fundamental role in gene expression. Molecules have been developed that interact with epigenetic marks on DNA. We have found that such molecules have strong anti-inflammatory effects in macrophages. We are investigating the epigenetic marks in macrophages, as well as inflammatory cells in inflamed tissues in conditions such as sepsis, rheumatoid arthritis, inflammatory bowel disease and other chronic inflammatory diseases. We also aim to characterise genetically modified mouse models of inflammation, as well as investigate preclinical models and clinical trial material.