Using a three-dimensional in vitro mouse ovarian culture model to create an artificial ovary is a Research Project for the Research Group, under the Using a three-dimensional in vitro mouse ovarian culture model to create an artificial ovary.
Many young female cancer patients undergo chemo- or radiation therapy, which introduces a risk of infertility. The in vitro growth and maturation of the ovarian follicle, which is the basic functional unit of the ovary, provides the potential to preserve fertility by growing follicles in vitro and transplanting them back into the patient. Growth and maturation of secondary follicles into large pre-ovulatory follicles, is essential to gaining insights into human folliculogenesis. Thus, the three-dimensional alginate in vitro follicle culture system is an excellent model to study the role of growth factors, metabolites and physical environment of the ovary.