Die Wang, Principal Scientist/Project Director

Die Wang is a research scientist and expert in structural and functional studies of proteins. His research interests lie primarily in understanding innate and antiviral immunity, together with biochemical research into innate immune function. He works on proteins that encode RNA-binding motifs that mediate the response of cells to RNA, to decipher their role in the response to stress and disease processes. He also performs functional assays to test the regulation of protein kinases in signal transduction pathways in inflammation and cancer. Furthermore, he conducts bioinformatics analyses to identify and characterise protein post-translational modifications, structure modelling, docking and dynamics simulations, to understand protein–protein and protein–oligonucleotide interactions.

Die Wang has worked with Professor Bryan Williams, head of the Cancer and Innate Immunity research group, since 2000. His current role is that of Principal Scientist and Project Director in the Cancer and Innate Immunity research group, working towards collaborative research projects in China.

Selected publications

  • Szczepny A, Carey K, McKenzie L, Jayasekara WSN, Rossello F, Gonzalez-Rajal A, McCaw AS, Popovski D, Wang D, Sadler AJ, Mahar A, Russell PA, Wright G, McCloy RA, Garama DJ, Gough DJ, Baylin SB, Burgess A, Cain JE, Watkins DN (2018) The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53. Oncogene 37:1939-1948.

  • Vasanthakumar A, Xu D, Lun AT, Kueh AJ, van Gisbergen KP, Iannarella N, Li X, Yu L, Wang D, Williams BR, Lee SC, Majewski IJ, Godfrey DI, Smyth GK, Alexander WS, Herold MJ, Kallies A, Nutt SL, Allan RS (2017) A non-canonical function of Ezh2 preserves immune homeostasis. EMBO Rep 18:619-631.

  • Wang D, de Weerd NA, Willard B, Polekhina G, Williams BR, Sadler AJ (2017) Auto-phosphorylation Represses Protein Kinase R Activity. Sci Rep 7:44340.

  • Yim HC, Wang D, Yu L, White CL, Faber PW, Williams BR, Sadler AJ (2016) The kinase activity of PKR represses inflammasome activity. Cell Res 26:367-379.

  • Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D (2015) BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci U S A 112:1535-1540.

  • Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST, Banerjee A, Mansell AS, Liu JP, Gerondakis S, Williams BR, Xu D (2015) The acetyltransferase HAT1 moderates the NF-kappaB response by regulating the transcription factor PLZF. Nat Commun 6:6795.

  • Liu MS, Wang D, Morimoto H, Yim HC, Irving AT, Williams BR, Sadler AJ (2014) Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation. J Mol Cell Biol 6:473-485.