Dr Jemma Evans is Deputy Head of the Endometrial Remodelling Laboratory in the Centre for Reproductive Health and is a Fielding Foundation Fellow. She works in the field of uterine biology. Dr Evans’ research is focused on understanding how the lining of the uterus becomes ready (receptive) for the implantation of an embryo, as well as the key controllers of communication between the uterus and the embryo.
This readiness and communication in the peri-implantation period is critical to understand new ways to 1) improve pregnancy rates in infertile couples and 2) target these critical factors to maintain the endometrium in a non-receptive state through the development of novel contraceptives.
It is becoming increasingly clear that the local environment within the uterus can have an effect on development of the baby. Optimising this environment is, therefore, critical in ensuring the health of both mother and baby.
Dr Evans’ current research focuses on the role of obesity-associated advanced glycation end products in uterine health and maternal-embryo communication. She is also examining the role of local exosomes in the uterine environment and how these may be altered in infertile women.
Evans J, Rai A, Nguyen HPT, Poh QH, Elglass K, Simpson RJ, Salamonsen LA, Greening DW (2019) In vitro human implantation model reveals a role for endometrial extracellular vesicles in embryo implantation: reprogramming the cellular and secreted proteome landscapes for bidirectional fetal-maternal communication. Proteomics 31800423.
Bellofiore N, Evans J (2019) Monkeys, mice and menses: the bloody anomaly of the spiny mouse. J Assist Reprod Genet. 36(5):811-817. Review.
Bellofiore N, Cousins F, Temple-Smith P, Evans J (2019) Altered exploratory behaviour and increased food intake in the spiny mouse before menstruation: a unique pre-clinical model for examining premenstrual syndrome. Hum Reprod. 34(2):308-322.
Evans J, Infusini G, McGovern J, Cuttle L, Webb A, Nebl T, Milla L, Kimble R,
Kempf M, Andrews CJ, Leavesley D, Salamonsen LA (2019) Menstrual fluid factors facilitate tissue repair: identification and functional action in endometrial and skin repair. FASEB J 33(1):584-605.
Bellofiore N, Cousins F, Temple-Smith P, Dickinson H, Evans J (2018) A missing piece: The spiny mouse and the puzzle of menstruating species. J Mol Endocrinol 61(1):R25-R41.
Antoniotti GS, Coughlan M, Salamonsen LA, Evans J (2018) Obesity associated advanced glycation end products within the human uterine cavity adversely impact endometrial function and embryo implantation. Hum Reprod 33(4): 654-665.
Whitby S, Salamonsen LA, Evans J (2018) The endometrial polarity paradox: Differential regulation of polarity within secretory-phase human endometrium. Endocrinology 159(1): 506-518.
Bellofiore N, Rana S, Dickinson H, Temple-Smith P, Evans J (2018) Characterization of human-like menstruation in the spiny mouse: Comparative studies with the human and induced mouse model. Hum Reprod 33(9): 1715-1726.
Evans J, Salamonsen LA, Winship A, Menkhorst E, Nie G, Gargett CE, Dimitriadis E (2016) Fertile ground: Human endometrial programming and lessons in health and disease. Nat Rev Endocrinol 12(11): 654-667.
Evans J (2016) Hyperglycosylated hCG: a unique human implantation and invasion factor. Am J Reprod Immunol 75(3): 333-340.
Evans J, Salamonsen LA, Menkhorst E, Dimitriadis E (2015) Dynamic changes in hyperglycosylated human chorionic gonadotrophin throughout the first trimester of pregnancy and its role in early placentation. Hum Reprod 30(5): 1029-1038.
Evans J, Hannan NJ, Edgell TA, Vollenhoven BJ, Lutjen PJ, Osianlis T, Salamonsen LA, Rombauts LJF (2014) Fresh versus frozen embryo transfer: Backing clinical decisions with scientific and clinical evidence. Hum Reprod Update 20(6): 808-821.
Evans J, Salamonsen LA (2014) Decidualized human endometrial stromal cells are sensors of hormone withdrawal in the menstrual inflammatory cascade. Biol Reprod 90(1):14.
Evans J, Salamonsen LA (2013) Too much of a good thing? Experimental evidence suggests prolonged exposure to hCG is detrimental to endometrial receptivity. Hum Reprod 28(6): 1610-1619.