Dr Padma Murthi is an internationally recognised placentologist. Her specific research expertise is in studying human placental development and function within nutrition, endocrinology and obstetrics research. Dr Murthi was awarded her PhD in 1995 from the University of Melbourne under the supervision of Professor Richard Larkins. From 2000 to 2014, Dr Murthi was employed at the Department of Obstetrics and Gynaecology, University of Melbourne and Department of Maternal-Fetal Medicine, Royal Women’s Hospital. In 2015, Dr Murthi was recruited to the Department of Medicine, School of Clinical Sciences, Monash University and The Ritchie Centre, Hudson Institute of Medical Research as a Senior Research Fellow.
Dr Murthi’s projects are focused on translational outcomes in obstetrics research. Her major research interests lie primarily in understanding the molecular mechanisms of placental insufficiency leading to human fetal growth restriction. She has generated more than 80 publications in this field. Her laboratory also studies the molecular targets of placental pathogenesis in preeclampsia and gestational diabetes during pregnancy.
Her current project investigates the specific role of placental tryptophan metabolism and its regulation by vitamin D in contributing to neurocognitive development in infants and children.
Dr Murthi also serves on the editorial boards of reproductive biology journals, Placenta and International Journal of Reproductive Sciences. She is the elected secretary of International Federation of Placental Associations.
Murthi P, Yong EJH, Nguyen TPH, Ellery S, Singh H, Rahman R, Dickinson H, Walker D, Wallace EM, Ebeling PR. Role of the Placental Vitamin D Receptor in Modulating Feto-Placental Growth in Fetal Growth Restriction and Preeclampsia-Affected Pregnancies. Frontiers in Physiology, 2016. doi.org/10.3389/fphys.2016.00043.
Murthi P, Brouillet S, Pratt A, Borg A, Kalionis B, Goffin F, Tsatsaris V, Munaut C, Feige J, Benharouga M, Fournier T, Alfaidy N. An EG-VEGF-dependent decrease in homeobox gene NKX3.1 contributes to cytotrophoblast dysfunction: a possible mechanism in human fetal growth restriction. Mol Med. 2015. doi: 10.2119/molmed.2015.00071.
Nguyen TP, Yong HE, Chollangi T, Borg AJ, Brennecke SP, Murthi P. Placental vitamin D receptor expression is decreased in human idiopathic fetal growth restriction. J Mol Med (Berl). 2015;93(7):795-805.
Borg AJ, Yong HE, Lappas M, Degrelle SA, Keogh RJ, Da Silva-Costa F, Fournier T, Abumaree M, Keelan JA, Kalionis B, Murthi P. Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction. Reproduction. 2015;149(5):523-32.
Pratt A, Da Silva Costa F, Borg AJ, Kalionis B, Keogh R, Murthi P. Placenta-derived angiogenic proteins and their contribution to the pathogenesis of preeclampsia. Angiogenesis. 2015;18(2):115-23.
E Holanda Moura SB, Park F, Murthi P, Martins WP, Kane SC, Williams P, Hyett J, Silva Costa Fd. TNF-R1 as a first trimester marker for prediction of pre-eclampsia. J Matern Fetal Neonatal Med. 2016;29(6):897-903
James JL, Hurley DG, Gamage TK, Zhang T, Vather R, Pantham P, Murthi P, Chamley LW. Isolation and characterisation of a novel trophoblast side-population from first trimester placentae. Reproduction. 2015;150(5):449-62.
Yong HE, Murthi P, Wong MH, Kalionis B, Brennecke SP, Keogh RJ. Anti-angiogenic collagen fragment arresten is increased from 16 weeks’ gestation in pre-eclamptic plasma. Placenta. 2015;36(11):1300-9.
Yong HE, Murthi P, Wong MH, Kalionis B, Cartwright JE, Brennecke SP, Keogh RJ. Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production. Pregnancy Hypertens. 2015; 5(4):346-53.
Murthi P. Review: placental homeobox genes and their role in regulating human fetal growth. Placenta. 2014;35 Suppl:S46-50.