Dr Sadler investigates components of our immune system. After completing his early research training in microbial genetics at the University of Canterbury and virology at the University of Otago he travelled to the US where he conducted postdoctoral research into host immune responses to microbial pathogens at the Learner Research Institute. In 2007, he came to Australia where he took up a position as a Senior Research Fellow within Hudson Institute. Dr Sadler investigates innate immune responses that regulate inflammation with the aim of identifying strategies to limit pathologies and treat ensuing disease.
His research currently focuses on three response molecules that together transduce cell signals and induce gene responses that he has shown control inflammation. Dr Sadler investigates a progression of immune pathologies from the initial responses to infection, through the development of chronic inflammatory conditions (colitis), to established chronic autoimmune diseases (type I diabetes and lupus).
- Treating infection-induced immune pathogenesis
- Evaluating interferon therapy against colitis
- Determining innate immune responses that induce type I diabetes
- Targeting cytokine signalling in systemic lupus erythematosus
Sadler AJ, Williams BR (2008) Interferon-inducible antiviral effectors. Nat Rev Immunol 8:559-568.
Sadler AJ, Latchoumanin O, Hawkes D, Mak J, Williams BR (2009) An antiviral response directed by PKR phosphorylation of the RNA helicase A. PLoS Pathog 5:e1000311.
Xu D, Holko M, Sadler AJ, Scott B, Higashiyama S, Berkofsky-Fessler W, McConnell MJ, Pandolfi PP, Licht JD, Williams BR (2009) Promyelocytic Leukemia Zinc Finger protein (ZBTB16) regulates interferon-mediated innate immunity. Immunity 30:802-816.
Irving AT, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton AH, Szczepny A, Morimoto H, Xu D, Williams BR, Sadler AJ (2012) Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defence. Immunity 36:795-806.
Dou Y, Yim HCH, Kirkwood CD, Williams BRG and Sadler AJ (2017) The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation. EMBO J 36:2742-2757.
Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D (2015) The BTB-ZF transcriptional regulator, PLZF (ZBTB16), modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci USA 112:1535-1540.
Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST, Banerjee A, Mansell AS, Liu JP, Gerondakis S, Williams BR, Xu D (2015) The Acetyltransferase HAT1 Moderates the NF-kB Response by Regulating the Transcription Factor PLZF (ZBTB16). Nat Commun 6:6795.
Yim HC, Wang D, Yu L, White CL, Faber PW, Williams BR, Sadler AJ (2016) The kinase activity of PKR represses inflammasome activity. Cell Res 26:367-379.