Dr Paule completed her PhD at Monash University in the Department of Biochemistry and Molecular Biology in 2006. Following her PhD, Dr Paule spent two years as a postdoctoral scientist at DiaB-tech, a drug development company in Melbourne. In 2009, she joined the Hudson Institute of Medical Research and changed her research field to reproductive biology within the Implantation and Placental Development Laboratory headed by Professor Guiying Nie. This laboratory is renowned for its research on uterine factors that contribute to the success or failure of embryo implantation and placental development.
Dr Paule’s research focuses on the remodelling of endometrium and, in particular, the epithelial cell surface which is the first point of contact between the embryo and endometrium. She is also interested in how progesterone regulates cell surface proteins for endometrial epithelial receptivity for embryo implantation and the pregnancy establishment.
Heng S, Paule SG, Li Y, Rombauts LJ, Vollenhoven B, Salamonsen LA, Nie G (2015) Posttranslational removal of α-dystroglycan N terminus by PC5/6 cleavage is important for uterine preparation for embryo implantation in women. FASEB . 29(9):4011-22.
Paule S, Nebl T, Webb AL, Vollenhoven B, Rombauts LJF, Nie G (2015) Proprotein convertase 5/6 cleaves platelet derived growth factor A in the human endometrium in preparation for embryo implantation. Mol Hum Reprod 21:262-270.
Ho H, Singh H, Heng S, Nero TL, Paule S, Parker MW, Johnson AT, Jiao GS, Nie G (2013) Small molecule proprotein convertase inhibitors for inhibition of embryo implantation. PLoS One 8(12):e81380.
Paule S, Aljofan M, Simon C, Rombauts LJ, Nie G (2012) Cleavage of endometrial α-integrins into their functional forms is mediated by proprotein convertase 5/6. Hum Reprod 27(9):2766-74.
Heng S, Cervero A, Simon C, Stephens AN, Li Y, Zhang J, Paule S, Rainczuk A, Singh H, Quinonero A, Tapia A, Velasquez L, Salamonsen L, Rombauts LJ, Nie G (2011) Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions. Endocrinology 152(12):5041-52.
Paule S, Meehan K, Rainczuk A, Stephens AN, Nie G (2011) Combination of hydrogel nanoparticles and proteomics to reveal secreted proteins associated with decidualization of human uterine stromal cells. Proteome Sci 9(1):50.
Paule S, Li Y, Nie G (2011) Cytoskeletal remodelling proteins identified in fetal-maternal interface in pregnant women and rhesus monkeys. J Mol Histol 42(2):161-6.
Paule SG, Airey LM, Li Y, Stephens AN, Nie G (2010) Proteomic approach identifies alterations in cytoskeletal remodelling proteins during decidualization of human endometrial stromal cells. J Proteome Res 9(11):5739-47.
Paule S, Heng S, Hardman B, Li Y, Singh H, Rainczuk A, Stephens AN, Nie (2010) Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment. Endocrinology 151(8):3909-17.