- Role: Postdoctoral ScientistGroup: Immunohaematology
Dr Tiwaporn (Tiwa) Nualkaew is a postdoctoral scientist in Immunohaematology research group. Her current work focuses mainly on developing novel gene therapy strategy for β-haemoglobinopathies. Her research involves the use of RNA interference and lentiviral vector technologies to manipulate α- and β-globin gene expression, the key factors contributing to disease pathology, in clinically relevant cellular model and patient-derived haematopoietic stem cells.
Dr Nualkaew completed her PhD in the Thalassemia Research Center at the Institute of Molecular Biosciences, Mahidol University, Thailand (2019), where she developed alternative gene-based therapeutic approaches for treatment of β-thalassaemias.
Nualkaew T, Khamphikham P, Pongpaksupasin P, Kaewsakulthong W, Songdej D, Paiboonsukwong K, Sripichai O, Engel JD, Hongeng S, Fucharoen S, Jearawiriyapaisarn N (2020) UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells. Ann Hematol doi:10.1007/s00277-020-04136-w. Online ahead of print.
Khamphikham P, Nualkaew T, Pongpaksupasin P, Kaewsakulthong W, Songdej D, Paiboonsukwong K, Engel JD, Hongeng S, Fucharoen S, Sripichai O, Jearawiriyapaisarn N (2020) High-level induction of fetal haemoglobin by pomalidomide in β-thalassaemia/HbE erythroid progenitor cells. Br J Haematol 189:e240-e245.
Nualkaew T, Jearawiriyapaisarn N, Hongeng S, Fucharoen S, Kole R, Svasti S (2019) Restoration of correct βIVS2-654-globin mRNA splicing and HbA production by engineered U7 snRNA in β-thalassaemia/HbE erythroid cells. Sci Rep 9:7672.
Preedagasamzin S, Nualkaew T, Pongrujikorn T, Jinawath N, Kole R, Fucharoen S, Jearawiriyapaisarn N, Svasti S (2018) Engineered U7 snRNA mediates sustained splicing correction in erythroid cells from β-thalassemia/HbE patients. Biochem Biophys Res Commun 499:86-92.
Phanthong P, Borwornpinyo S, Kitiyanant N, Jearawiriyapaisarn N, Nuntakarn L, Saetan J, Nualkaew T, Sa-Ngiamsuntorn K, Anurathapan U, Dinnyes A, Kitiyanant Y, Hongeng S (2017) Enhancement of β-globin gene expression in Thalassemic IVS2-654 induced pluripotent stem cell-derived erythroid cells by modified U7 snRNA. Stem Cells Transl Med 6:1059-1069.