Dr Yiqian Chen completed her PhD in the Centenary Institute of Cancer Medicine and Cell Biology at the University of Sydney. Dr Chen’s previous work largely centred around the biological functions and therapeutic potential of dipeptidyl peptidases. Her early scientific work helped to establish the safe application of their inhibitors as a therapy for type 2 diabetes and cancer. In late 2016, she started her postdoctoral training in the Ovarian Cancer Biomarkers laboratory at Hudson Institute of Medical Research. Her current work is involved in understanding the role of dipeptidyl peptidases in ovarian cancer. She is also working to establish the direct effects of the photosensitiser on ovarian cancer cells.
Selected publications
Chen Y, Gall MG, Zhang H, Keane FM, McCaughan GW, Yu DM, Gorrell MD (2016) Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Experimental Cell Research 342:72-82.
Zhang H, Chen Y, Wadham C, McCaughan GW, Keane FM, Gorrell MD (2015) Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. BBA-Molecular Cell Research 1853:470-480.
Osborne B, Yao TW, Wang XM, Chen Y, Kotan LD, Nadvi NA, Herdem M, McCaughan GW, Allen JD, Yu DMT, Topaloglu AK, Gorrell MD (2014) A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. BBA-Proteins and Proteomics 1844:1248-1259.
Gall MG, Chen Y, Ribeiro AJV, Zhang H, Bailey CG, Spielman DS, Yu DMT, Gorrell MD (2013) Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality. PLoS One 8:e78378.
Zhang H, Chen Y, Keane FM, Gorrell MD (2013) Advances in understanding the expression and function of dipeptidyl peptidase 8 and 9. Molecular Cancer Research 11:1487-1496.
Chowdhury S, Chen Y, Yao TW, Ajami K, Wang XM, Popov Y, Schuppan D, Bertolino P, McCaughan GW, Yu DMT, Gorrell MD (2013) Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World J Gastroenterol 19:2883-2893.