Dr Yiqian Chen

Dr Yiqian Chen is a Postdoctoral Scientist within the Ovarian Cancer Biomarkers Research Group. Yiqian is working on the Invion Limited-sponsored research project to advance Invion’s cancer treatment technology, PhotosoftTM. Photosoft™ is a next generation Photodynamic Therapy (PDT). PDT is a minimally invasive therapeutic treatment that uses non-toxic photosensitisers and visible light in combination with oxygen to produce cytotoxic Reactive Oxygen Species (ROS) with the aim of killing malignant cells and stimulating the immune system.

Selected publications

  • Chen Y, Gall MG, Zhang H, Keane FM, McCaughan GW, Yu DM, Gorrell MD (2016) Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Exp Cell Res 342:72-82.

  • Zhang H, Chen Y, Wadham C, McCaughan GW, Keane FM, Gorrell MD (2015) Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochim Biophys Acta 1853:470-480.

  • Osborne B, Yao TW, Wang XM, Chen Y, Kotan LD, Nadvi NA, Herdem M, McCaughan GW, Allen JD, Yu DMT, Topaloglu AK, Gorrell MD (2014) A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochim Biophys Acta 1844:1248-1259.

  • Gall MG, Chen Y, Ribeiro AJV, Zhang H, Bailey CG, Spielman DS, Yu DMT, Gorrell MD (2013) Targeted inactivation of dipeptidyl peptidase 9 enzymatic activity causes mouse neonate lethality. PLoS One 8:e78378.

  • Zhang H, Chen Y, Keane FM, Gorrell MD (2013) Advances in understanding the expression and function of dipeptidyl peptidase 8 and 9. Mol Cancer Res 11:1487-1496.

  • Chowdhury S, Chen Y, Yao TW, Ajami K, Wang XM, Popov Y, Schuppan D, Bertolino P, McCaughan GW, Yu DMT, Gorrell MD (2013) Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World J Gastroenterol 19:2883-2893.