Dr Virginie Deswaerte
This review highlights recent advancements in our understanding of the transcriptional regulation of genes encoding inflammasome- associated innate immune receptors, and the impact on a variety of cellular responses during disease pathogenesis.
Centre for Innate Immunity & Infectious Diseases
Cancer and Immune Signalling Laboratory
Journal and article title
The dysregulated expression and/or activation of inflammasomes is increasingly implicated in numerous disease states, such as chronic auto-inflammatory and autoimmune disorders, metabolic syndrome, neurodegenerative and cardiovascular diseases, as well as cancer.
A better understanding of the mechanisms regulating the inflammasome, and the involvement of such mechanisms in the pathogenesis of human diseases, has potential to assist the development of novel targeted treatments.