Project description

Impaired differentiation is a common feature of cancer. We have recently demonstrated the differentiation potential of histone deacetylase inhibitors (HDACi) in paediatric (rhabdoid tumours) and adult (lung adenocarcinoma) solid tumours that are genetically defined by mutations in the SWI/SNF chromatin remodelling complex. Recent genomic studies have shown that mutations in subunits of this complex occur in at least 20% of all cancer. Using preclinical models of SWI/SNF-deficient and intact cancers, the successful candidate will investigate the mechanisms of epigenetic-mediated differentiation and apply these findings to a broader clinical context.

Please email me directly with enquiries: jason.cain@hudson.org.au