Endometrial Remodelling Research Group
Research Group Head
The lining of the uterus, the endometrium, undergoes continual remodelling throughout a woman’s reproductive years. During each menstrual cycle, the endometrium sheds and restores in preparation for implantation of the embryo, should conception occur. Disturbances to this remodelling can result in abnormal uterine bleeding, infertility, endometriosis, and endometrial cancer. The group aims to translate knowledge of endometrial repair and embryo implantation to provide treatments for uterine bleeding problems and improve success rates and long-term health outcomes for IVF. In a broader context, the team also hopes to apply knowledge of endometrial repair to help develop new ways to improve the treatment of chronic wounds and reduce scarring.
- Uterine fluid: the microenvironment of embryo implantation is critical for successful pregnancy
- Endometrial Repair
- Exosomes: a new paradigm for embryo-maternal interactions at implantation
Ng YH, Rome S, Jalabert A, Forterre A, Singh H, Hincks CL, Salamonsen LA (2013) Endometrial exosomes in the uterine microenvironment: a new paradigm for embryo-endometrial cross talk at implantation. PLOS One 8(3):e58502.Evans J, Salamonsen LA (2013) Too much of a good thing? Experimental evidence suggests prolonged exposure to hCG is detrimental to endometrial receptivity. Hum Reprod. 28: 1610-1619.Evans J, Salamonsen LA (2014) Decidualized human endometrial stromal cells are sensors of hormone withdrawal in the menstrual cascade. Biology of Reproduction, 90(1):14, 1–12
Edgell TA, Rombauts LJF, Salamonsen LA (2013) Assessing receptivity in the endometrium: the need for a rapid, non-invasive test. Reprod Biomed Online Reprod Biomed Online. 2013 Nov;27(5):486-96. doi: 10.1016/j.rbmo.2013.05.01
Evans J, Rombauts LJF, Hannan NJ, Edgell, T, Vollenhoven BJ, Lutjen PJ, Osianlis T, Salamonsen LA. (2014) Fresh vs Frozen Embryo Transfer: backing clinical decisions with science. Human Reproduction Update (E-pub, pii: dmu027).