Dr Rebecca Lim

Biography

Dr Rebecca Lim was awarded her PhD from the University of Western Australia. She currently leads a dynamic research group at The Ritchie Centre, where she is mentored by and works closely with Professor Euan Wallace AM. Dr Lim is presently a Chief Investigator on four NHMRC project grants. She is also an investigator on two clinical trials at Monash Health.

The core research of Dr Lim’s laboratory is in the area of stem cell biology and regenerative medicine. Her research team is focused on uncovering the regenerative potential of amnion derived stem-like cells while concurrently pursuing clinical translation of her findings. In recent years, her team has uncovered key immunological events that are critical to the success of amnion cell mediated lung repair in the settings of adult and neonatal lung disease. More recently her team has shown that amnion cells trigger endogenous repair processes by activating the adult stem cell niche and recruiting distal progenitor sites to the area of injury. She collaborates widely and looks to apply amnion cells across a variety of acute and chronic conditions in an effort to understand their potential and limitations.

Selected publications

  • Murphy, S.V. Reid, T., Atala, A., Wallace, E.M., Lim, R. (2014). Isolation, cryopreservation and culture of human amnion epithelial cells for clinical applications. Journal of Visualised Experiments. Accepted 16th May 2014.

  • Zhu, D., Wallace, E.M., Lim, R. (2014) Cell-based therapies for diseases of prematurity. Cytotherapy. Accepted 30thJanuary 2014.

  • Lim, R., Tan J.L. Wallace, E.M. (2013) Cell Therapies For Lung Disease. In: Gene and Cell Therapies, 4th Edition. Edited by Templeton, N. S. Taylor & Francis Group, CRC Press.

  • Lim, R., Chan, S.T., Tan, J.L., Murphy, S.V., Mockler, J.E., Wallace, E.M. (2013) Preterm human amnion epithelial cells have limited reparative potential. Placenta. 34: 486-492.

  • Vosdoganes, P., Lim, R., Kouleava, E., Chan, S.T., Acharya, R., Moss, T.J.M., Wallace, E.M. (2013) Human amnion epithelial cells modulate hyperoxia-induced neonatal lung injury in mice. Cytotherapy. 2013 Apr 30. doi:pii: S1465-3249(13)00452-0. 10.1016/j.jcyt.2013.03.004.

  • Tan, J.L., Chan, S.T., Wallace, E.M., Lim, R. (2013) Human amnion epithelial cells mediate lung repair by directly modulating macrophage recruitment and polarization. Cell Transplantation. Epub ahead of print. 2013 Jan 2.

  • Lim, R., Milton, P-L., Chan, S.T., Acharya, R., Murphy, M., Jenkin, G. (2013) Human mesenchymal stem cells reduce lung injury in immunocompromised mice but not immunocompetent mice. Respiration. 85 (4):332-41.

  • Murphy, S., Lim, R., Heraud, P., Cholewa, M., Le Gros, M., de Jonge, M.D., Howard, D.L., Paterson, D., McDonald, C., Atala, A., Jenkin, G., Wallace, E.M. (2012) Human amnion epithelial cells induced to express functional Cystic Fibrosis transmembrane conductance regulator. Plos One 7(9):e46533. doi: 10.1371/journal.pone.0046533. Epub 2012 Sep 28.

  • Vosdoganes, P., Lim, R., Moss, T.J.M., Wallace, E.M. (2012) Cell Therapy: a novel approach in the treatment of bronchopulmonary dysplasia. Pediatrics.130(4):727-37

  • Murphy, S., Chin, S., Tan, J.L., Chan, S., Jenkin, G., Wallace, E.M., Lim, R.(2012)Human Amnion Epithelial Cells Do Not Abrogate Pulmonary Fibrosis in Mice With Impaired Macrophage Function. Cell Transplantation. 21(7): 1477-1492

  • Hodges, R., Vosdoganes, P., Westover, W., Moss, T.J. Alison, B., Hooper, S., Miller, S.L., Lim, R., Dickinson, D., Wallace, E.M. (2012) Human amnion epithelial cells reduce ventilation-induced preterm lung injury in fetal sheep. Am J Obstet Gynaceol. 206(5):448.e8-15. Epub 2012 Mar 7.

  • Vosdoganes, P., Wallace, E.M., Chan S.T., Acharya, R., Moss, T.J.M., Lim, R. (2012) Human amnion epithelial cells repair established lung injury. Cell Transplant. 2013;22(8):1337-49. doi: 10.3727/096368912X657657. Epub 2012 Oct 4.

  • Murphy, S., Lim. R., Dickinson, H., Rosli, Acharya, R., Jenkin, G., Wallace, E. (2011) Human amnion epithelial cell prevent bleomycin induced lung injury and restore lung function. Cell Transplantation.20(6): 909-923.

  • Vosdoganes, P., Hodges, R.J., Lim, R., Westover, A.J., Acharya, R.Y., Wallace, E. (2011). Human amnion epithelial cells as a treatment for inflammation induced fetal lung injury in sheep. American Journal of Obsterics and Gynaecology. 205 (156): 26-33.