Childhood brain cancer

Jaxon cancer patient at Hudson Institute

Childhood brain cancer

Every year, 1,700 people are diagnosed with brain cancer in Australia, including 190 children who are diagnosed with childhood brain cancer. About 1,200 Australians die of the disease annually.

There are approximately 80 different types of malignant (cancerous) brain tumours that occur in children.

Our childhood brain cancer research

The Hudson Monash Paediatric Precision Medicine (HMPPMP) is a cross-institutional discovery and translational research program at Hudson Institute of Medical Research, that aims to significantly improve the treatment, survival and quality of life for children with cancer, with a special focus on brain cancer.

Through the extensive and ground-breaking work of the HMPPMP, Hudson Institute scientists are accelerating medical research into childhood cancers and the discovery of lifesaving treatments.

With funding from the Children’s Cancer Foundation since 2017, the HMPPMP has established one of the largest biobank repositories of childhood cancer models in the world.  Now, using state-of-the art functional genomic and multi-dimensional profiling technologies, the biobank is being used to develop the next generation of precision oncology treatments for paediatric cancer patients. 

Brain Cancer Atlas Project – a platform for identifying the next generation of targeted therapies

This project brings together an international team of clinicians, researchers and data bioinformaticians to

Associate Professor Ron Firestein from the Cancer Genetics and Functional Genomics Research Group at Hudson Institute

  1. Develop and characterise new models of adult, adolescent and childhood brain cancers
  2. Conduct functional screens (CRISPR, drug screens) to identify genetic vulnerabilities and dependencies in brain cancer
  3. Utilise computational approaches (e.g. machine-based learning) to predict therapeutic responses based on molecular features.

Identification of pathway dependencies in childhood brain tumours

AIM BRAIN: Access to Innovative Molecular Diagnostic Profiling for Paediatric Brain Tumours

Childhood brain cancer collaborators

Support for families and children with brain cancer

Our scientists cannot provide medical advice.
If you would like to find out more information about brain cancer, please visit

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