Dr Gina Kusuma

Gina obtained her PhD from the University of Melbourne in 2015 and her PhD work laid the foundation for preeclampsia management by restoring oxidative response in placental stem cells.

Her current research focuses on the clinical scale production of exosomes and bioengineering stem cells therapeutic effect. Her research interests include stem cells, lung fibrosis, microRNA signalling, extracellular vesicles, and regenerative medicine

Selected publications

  • Frith JE, Kusuma GD, Carthew J, Li F, Cloonan N, Gomez GA, Cooper-White JJ (2018) Mechanically-sensitive miRNAs bias human mesenchymal stem cell fate via mTOR signalling. Nature Communications. 9, 1, 12 p., 257.

  • Kusuma GD, Abumaree MH, Pertile MD, Kalionis B (2018) Isolation and characterization of mesenchymal stem/stromal cells derived from human third trimester placental chorionic villi and decidua basalis. Methods in Molecular Biology; vol. 1710, 247-266.

  • Kusuma GD, Yang M, Brennecke S, O’Connor AJ, Kalionis B, Heath DE (2018) Transferable Matrixes Produced from Decellularized Extracellular Matrix Promote Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells and Facilitate Scale-Up. ACS Biomaterials Science and Engineering. 4, 5, p. 1760-1769 10 p.

  • Kusuma GD, Carthew J, Lim R, Frith JE (2017) Effect of the microenvironment on mesenchymal stem cell paracrine signaling: Opportunities to engineer the therapeutic effect. Stem Cells and Development. 26, 9, p. 617-631 15 p.

  • Kusuma GD, Brennecke SP, O’Connor AJ, Kalionis B, Heath DE (2017) Decellularized extracellular matrices produced from immortal cell lines derived from different parts of the placenta support primary mesenchymal stem cell expansion. PLoS ONE. 12(2): e0171488.

  • Kusuma GD, Abumaree MH, Perkins AV, Brenneck SP, Kalionis B (2017) Reduced aldehyde dehydrogenase expression in preeclamptic decidual mesenchymal stem/stromal cells is restored by aldehyde dehydrogenase agonists. Scientific Reports. 7, 42397

  • Qin SQ, Kusuma GD, Al-Sowayan B, Pace RA, Isenmann, S, Pertile MD, Gronthos S, Abumaree MH, Brennecke SP, Kalionis B (2016) Establishment and characterization of fetal and maternal mesenchymal stem/stromal cell lines from the human term placenta. Placenta. 39, p. 134-146 13 p.

  • Kusuma GD, Abumaree MH, Pertile MD, Perkins AV, Brennecke SP, Kalionis B (2016) Mesenchymal Stem/Stromal Cells Derived from a Reproductive Tissue Niche Under Oxidative Stress Have High Aldehyde Dehydrogenase Activity. Stem Cell Reviews. 12, 3, p. 285-297 13 p.

  • Kusuma GD, Murthi P, Kalionis B (2016) The Role of Mesenchymal Stem Cells in the Functions and Pathologies of the Human Placenta. Placenta: The Tree of Life. Parolini, O. (ed.). CRC Press, p. 13-38 26 p. (Gene and Cell Therapy Series)

  • Kusuma GD, Menicanin D, Gronthos S, Manuelpillai U, Abumaree MH, Pertile MD, Brennecke SP, Kalionis B (2015) Ectopic bone formation by mesenchymal stem cells derived from human term placenta and the decidua. PLoS ONE. 10, 10, e0141246

  • Kusuma GD, Manuelpillai UC, Abumaree M, Pertile MD, Brennecke SP, Kalionis B (2015) Mesenchymal stem cells reside in a vascular niche in the decidua basalis and are absent in remodelled spiral arterioles. Placenta. 36, 3, p. 312-321 10 p.

  • Liu H, Murthi P, Qin S, Kusuma GD, Borg AJ, Knofler M, Haslinger P, Manuelpillai UC, Pertile MD, Abumaree M, Kalionis B (2014) A novel combination of homeobox genes is expressed in mesenchymal chorionic stem/stromal cells in first trimester and term pregnancies. Reproductive Sciences. 21, 11, p. 1382 – 1394 13 p.

  • Castrechini NM, Murthi P, Qin JS, Kusuma GD, Wilton L, Abumaree, MH, Gronthos S, Zannettino ACW, Gude NM, Brennecke SP, Kalionis B (2012) Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua. Reproductive Sciences. 19, 12, p. 1302-1314 13 p.