Areas of interest
Childhood cancer Pancreatic cancer Sarcoma
Research group
Translational Antigen Discovery
Biography
Following postdoctoral research with Prof Alan Mark at The University of Queensland and subsequent work with A/Prof Ashley Buckle at Monash University, Dr Kass transitioned to the biotech industry, applying computational approaches to investigate protein structure, dynamics, function, and regulation. His expertise spans molecular-dynamics simulation, physics-based molecular modelling and AI/ML-assisted approaches for structural biology, protein engineering, and structure-based discovery.
Education
| PhD | The Hebrew University | Jerusalem, Israel |
| MSc | Weizmann Institute of Science | Rehovot, Israel |
Publication highlights
Kunnath SM, Arad E, Zalk R, Kass I, Shahar A, Batushansky A, Rapaport H, Jelinek R (2025) Allosteric amyloid catalysis by coiled coil fibrils. Nat Commun 16:5071. doi: 10.1038/s41467-025-60379-z.
Adam S, Kass I, Krepel-Zussman D, Masarati G, Shemesh D, Sharir-Ivry A (2024) Effect of protein-polarized ligand charges on relative protein ligand binding affinities. J Chem Theory Comput 20 8270-8278. https://doi.org/10.1021/acs.jctc.3c01337
Fodor J, Riley BT, Kass I, Buckle AM, Borg NA (2019) The Role of Conformational Dynamics in Abacavir-Induced Hypersensitivity Syndrome. Sci Rep 9:10523. doi: 10.1038/s41598-019-47001-1.
Kass I, Buckle AM, Borg NA (2014) Understanding the structural dynamics of TCR-pMHC complex interactions. Trends Immunol 35:604-612. doi: 10.1016/j.it.2014.10.005.
Kass I, Hoke DE, Costa MG, Reboul CF, Porebski BT, Cowieson NP, Leh H, Pennacchietti E, McCoey J, Kleifeld O, Borri Voltattorni C, Langley D, Roome B, Mackay IR, Christ D, Perahia D, Buckle M, Paiardini A, De Biase D, Buckle AM (2014) Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis. Proc Natl Acad Sci U S A 111:E2524-9. doi: 10.1073/pnas.1403182111.
Kass I, Knaupp AS, Bottomley SP, Buckle AM (2012) Conformational properties of the disease-causing Z variant of α1-antitrypsin revealed by theory and experiment. Biophys J 102:2856-2865. doi: 10.1016/j.bpj.2012.05.023.
