Project description

Extracellular vesicles are nanoparticles that contain bioactive cargo and provide crucial information about the donor cell’s identity and functional contribution to the recipient cells.
The endometrium undergoes significant changes during the menstrual cycle. The decidua is effectively shed as menses at the end of a non-conception cycle, and the endometrium rapidly re-epithelialises and regenerates. We based our study on the retrograde menstruation hypothesis for the pathogenesis of endometriosis. This project will investigate reproductive biofluid-derived extracellular vesicles to understand the pathogenesis and identify non-invasive early diagnosis and screening for endometriosis