Project description

Endometriosis is a chronic, severe disease characterised by the presence of endometrial-like tissue outside of the uterus and occurs in 1 in 7 women or people. 30-50% of women with endometriosis have infertility. The endometrium (lining of the uterus) completely remodels during the menstrual cycle to become receptive to the implanting embryo. The impact of endometriosis on the endometrium and fertility remains largely unknown. This project utilises multicellular human endometrial organoids to investigate how endometriosis affects the hormone response of the endometrium and its ability to become receptive.