Project description

Our work is focussed on understanding the roles and functions of A-to-I RNA editing by the ADAR family of proteins. ADAR proteins can bind to RNA and change adenosine bases to inosine. Editing by ADAR1 is essential that cells can tell the difference between RNAs that are made by the cell and so not a threat compared to nucleic acids derived from pathogens such as viruses that invade the cell. We are interesting in understanding other types and sources of cellular derived immunogenic RNA. We will use new models to understand if cellular RNA. Expressed through different stimuli or with different modifications, changes its immunogenicity and what can sense these. We will use cell line model, genetics, biochemistry and computational analysis. This will enable us to better understand how immunogenic cellular RNAs can be managed to prevent unwanted autoimmunity.