– Activin Follistatin Biology and Inflammation
– Embryo Implantation
– Endocrinology and immunophysiology
– Endometrial Remodelling
– Implantation and Placental Development
– Male Fertility Regulation
– Testis Development and Male Germ Cell Biology
Research > Centre for Reproductive Health
Centre Head, Professor Kate Loveland
Monash Institute and Prince Henry’s Institute of Medical Research have been internationally recognised for their outstanding research into reproductive processes for more than 40 years. The current research program of the Hudson Institute’s Centre for Reproductive Health is strongly based in both basic and translational science. Reproductive Health is now a key global challenge, with impacts of the environment and changes in societies strongly impacting not only on both male and female reproduction but also on the long-term health of their offspring. The latter detrimental changes are established both in the sperm and egg, and during early development of the conceptus.
With a rapidly increasing world population, the need for new contraceptive options has never been greater. Furthermore, translation of advances in reproductive sciences also impacts on cancer biology, animal food production, and conservation of endangered species. In addition, proteins involved in the regulation of reproduction also have wider actions influencing inflammation and tissue repair in a wide variety of organs.
Our laboratories and research areas:
- Uterine Biology Three teams undertaking highly complementary work on uterine receptivity, implantation and placentation, endometrial cancer, and contraceptive development. Individual team focus:
- Endometrial Remodelling The intrauterine microenvironment of implantation; endometrial repair: embryo-maternal interactions via exosomes, tests for endometrial receptivity
- Embryo Implantation Embryo-maternal interactions: miRNA and embryo factors; placental development; endometrial cancer
- Implantation and Placentation Molecular changes during placentation; pre-eclampsia; post-translational changes during implantation and placentation
- Ovarian Biology Mechanisms that control egg supply and health during ovarian development and throughout reproductive life. Strategies for preservation of fertility during chemotherapy and radiation treatment
- Male Reproductive Immunology Understanding immune privilege in reproductive tissues; roles of ‘reproductive hormones’ inhibins, activins and follistatin in the control of inflammation and tissue repair; lymphocytes and macrophages in male reproductive function
- Spermatozoal Development Potential sites of action of male contraception: hormonal regulation of Sertoli cell junctions; minimally invasive diagnostic testing for testicular function
- Brain and Gender Brain sexual differentiation and gender bias in diseases such as Parkinson’s disease, ADHD and schizophrenia towards improved therapies.