Dr Christine White

Dr Christine White works with A/Prof Elizabeth Algar in the Genetics and Molecular Pathology laboratory, establishing a diagnostic platform for molecular profiling of childhood brain tumours. This technology, currently only available overseas, will allow Australian and New Zealand patients to obtain a more precise diagnosis of their disease.

Dr White completed her BSc (Hons) at the John Curtin School of Medical Research at the Australian National University. She completed her PhD at the Walter and Eliza Hall Institute of Medical Research, where she studied innate immune signalling. She then moved to Cleveland, OH, USA for postdoctoral training with Professor Bryan Williams and Dr Ganes Sen, in which she completed a variety of projects which focused on the role of Interferon signalling in development. In 2014, she began working with Dr Daniel Gough in the STAT Cancer Biology laboratory in the Centre for Cancer Research at the Hudson Institute studying the role of STAT3 in childhood brain tumours.

Selected publications

  • Baroni L, Sundaresan, L, Heled, A, Coltin H, Pajtler KW, Lin T, Merchant TE, McLendon R, Faria C, Buntine M, White CL, Pfister SM, Gilbert MR, Armstrong TS, Bouffet, E, Kumar S, Taylor MD, Aldape KD, Ellison DW, Gottardo NG, Kool M, Korshunov A, Hansford JR, Ramaswamy V (2021) Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q.  Neuro Oncol.doi:10.1093/neuonc/noab034 online ahead of print.

  • Whitehouse JP, Howlett M, Hii H, Mayoh C, Wong M, Barahona P, Ajuyah P, White CL, Buntine MK, Dyke JM, Lee S, Valvi S, Stanley J, Andradas C, Carline B, Kuchibhotla, M, Ekert PG, Cowley, MJ, Gottardo, NG, Endersby R (2020) A Novel Orthotopic Patient-Derived Xenograft Model of Radiation-Induced Glioma Following Medulloblastoma. Cancers (Basel) 12:2937.

  • Balic, JJ, White, CL, Dawson R, Gough D, McCormack, MP, Jenkins, BJ (2020) STAT3-driven hematopoiesis and lymphopoiesis abnormalities are dependent on serine phosphorylation. Cytokine 130:155059.

  • White CL, Jayasekara WSN, Picard D, Chen J, Watkins DN, Cain JE, Remke M, Gough DJ (2019) A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma. Cancers (Basel) 11:1702; doi:10.3390/cancers11111702.

  • Garama DJ, White CL, Balic JJ, Gough DJ (2016) Mitochondrial STAT3: Powering up a Potent Factor. Cytokine 87:20-25.

  • White CL, Kessler PM, Dickerman BK, Ozato K, Sen GC (2016) Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members. (2016). J Biol Chem 291:13535-13545.

  • Yim HCH, Wang D, Yu L, White CL, Faber PW, Williams BRG, Sadler AJ (2016) The Role of PKR in Inflammasome Activation. Cell Res 26:367-379.

  • Garama DJ, Harris TJ, White CL, Rosello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species provides a Tumour Specific Vulnerability Dependent on STAT3. Mol Cell Biol 35:3646-3656.

  • *Dickerman BK, *White CL, Kessler PM, Sadler AJ, Williams BRG, Sen GC (2015) The Protein Activator of PKR PACT/RAX Negatively Regulates PKR During Mouse Anterior Pituitary Development.  FEBS J  282:4766-4781.  * denotes equally contributing first authors.

  • Dickerman BK, White CL, Chevalier C, Nalesso V, Charles C, Fouchécourt S, Guillou F, Viriot L, Sen GC, Hérault Y (2011) Missense Mutation in the Second RNA Binding Domain Reveals a Role for Prkra (PACT/RAX) during Skull Development.  PLoS ONE 6:e28537.

  • White CL, Chattopadhyay S, Sen GC (2011) Phosphatidylinositol 3-Kinase Signaling Delays Sendai Virus-Induced Apoptosis by Preventing XIAP Degradation. J Virol 85:5224-5227.